T4626

N_α-p-Tosyl-L-arginin-methylester -hydrochlorid

≥98% (TLC), suitable for ligand binding assays

• Synonym(e): TAME
• Lineare Formel: H₂NC(=NH)NH(CH₂)₃CH(NHSO₂C₆H₄CH₃)CO₂CH₃ · HCl
• CAS-Nummer: 1784-03-8
• Molekulargewicht: 378.87
• Beilstein: 3922357
• EG-Nummer: 217-235-1
• MDL-Nummer: MFCD00012578
• UNSPSC-Code: 12352103
• eCl@ss: 32160406
• PubChem Substanz-ID: 24900058
• NACRES: NA.26

Eigenschaften

• Produktbezeichnung: N_α-p-Tosyl-L-arginin-methylester -hydrochlorid,
• Assay: ≥98% (TLC)
• Qualitätsniveau: 200
• Form: powder
• Methode(n): ligand binding assay: suitable
• Farbe: white
• mp (Schmelzpunkt): 145-147 (lit.)
• Lagertemp.: −20°C
• SMILES String: Cl.COC(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1ccc(C)cc1
• InChI: 1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H/t12-;/m0./s1
• InChIKey: JIQFFACVQXXHMY-YDALLXLXSA-N

Beschreibung

Anwendung

Nα-p-Tosyl-L-arginine methyl ester hydrochloride has been used as an esterolytic substrate to assess trypsin-like activity in midgut extracts.[1] It has also been used as a substrate for measuring trypsin activity of pancreatin[2] and human intestinal samples.[3]

Biochem./physiol. Wirkung

N_α-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1.

Substrate

Substrate for trypsin,[4] thrombin,[4] plasmin,[5] and other proteases.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)