T2057

Trequinsin hydrochloride

≥98%

• Synonym(e): HL 725
• Empirische Formel (Hill-System): C₂₄H₂₇N₃O₃ · HCl
• CAS-Nummer: 78416-81-6
• Molekulargewicht: 441.95
• MDL-Nummer: MFCD01076563
• UNSPSC-Code: 41106305
• PubChem Substanz-ID: 24278727
• NACRES: NA.77

Eigenschaften

• Assay: ≥98%
• Form: powder
• SMILES String: Cl[H].COc1cc2CCN3C(=O)N(C)C(\C=C3c2cc1OC)=N\c4c(C)cc(C)cc4C
• InChI: 1S/C24H27N3O3.ClH/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4;/h9-13H,7-8H2,1-6H3;1H/b25-22+;
• InChIKey: DTCZZBVPTHVXFA-OSMRDGEFSA-N
• Angaben zum Gen: human ... PDE3A(5139) , PDE3B(5140)

Beschreibung

Anwendung

Trequinsin has been used as a PDE3 inhibitor in rat juxtaglomerular cells. This study reported that trequinsin can enhance cellular cAMP content, forskolin-induced cAMP synthesis, and renin release in cells[1].

Biochem./physiol. Wirkung

Phosphodiesterase III inhibitor.

Trequinsin is a strong antihypertensive agent that has a hemodynamic profile similar to that of arteriolar dilators. Trequinsin can block platelet aggregation and also inhibit tissue factor expression in human endothelial cells[2],[3].

Leistungsmerkmale und Vorteile

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)