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SRP5021

Sigma-Aldrich

DUSP22, active, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(e):

JKAP, JSP1, VHX

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About This Item

UNSPSC-Code:
12352202
NACRES:
NA.32

Rekombinant

expressed in E. coli

Assay

≥70% (SDS-PAGE)

Form

buffered aqueous glycerol solution

Spezifische Aktivität

510-690 nmol/min·mg

Mol-Gew.

~43 kDa

NCBI-Hinterlegungsnummer

NM_020185

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... DUSP22(56940)

Allgemeine Beschreibung

Dual specificity phosphatases (DUSP) family, which can dephosphorylate both phosphoserine/threonine and phosphotyrosine residues, comprise of two subgroups: "typical" DUSP (include 11 MKPs that dephosphorylate the mitogen-activated protein kinases Erk, Jnk, and p38 at their dually phosphorylated TXY activation loop motif) and "atypical" DUSP (include 8 enzymes that lack specific MAP kinase-targeting motifs and tend to be much smaller proteins, which are less than 250 amino acid residues). DUSP22, also called JKAP, JSP1 and MKPX plays a role in various inflammatory and proliferative disorders associated with dysfunctional Jnk signaling.

Physikalische Form

Supplied in 20mM MOPS, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 30% glycerol.

Angaben zur Herstellung

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Andres Alonso et al.
The Journal of biological chemistry, 279(31), 32586-32591 (2004-05-13)
The human DUSP15 gene encodes an uncharacterized 235-amino acid member of the subfamily of small dual specificity protein phosphatases related to the Vaccinia virus VH1 phosphatase. Similar to VHR-related MKPX (VHX) (DUSP22), the predicted protein has an N-terminal myristoylation recognition
Y Shen et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(24), 13613-13618 (2001-11-22)
The mitogen-activated protein kinases (MAPKs) are integral to the mechanisms by which cells respond to physiological stimuli, such as growth factors, hormones, and cytokines, and to a wide variety of environmental stresses. The MAPKs, which are stimulated by phosphorylation of

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