SML1183

BMH-21

≥98% (HPLC)

• Synonym(e): N-[2-(Dimethylamino)ethyl]-12-oxo-2H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
• Empirische Formel (Hill-System): C₂₁H₂₀N₄O₂
• CAS-Nummer: 896705-16-1
• Molekulargewicht: 360.41
• MDL-Nummer: MFCD27225377
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825705
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: faint yellow to dark orange
• Löslichkeit: DMSO: 1 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: O=C(N(C=CC=C1C(NCCN(C)C)=O)C1=N2)C(C2=C3)=CC4=C3C=CC=C4
• InChI: 1S/C21H20N4O2/c1-24(2)11-9-22-20(26)16-8-5-10-25-19(16)23-18-13-15-7-4-3-6-14(15)12-17(18)21(25)27/h3-8,10,12-13H,9,11H2,1-2H3,(H,22,26)
• InChIKey: BXYDVWIAGDJBEC-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

BMH-21 is a planar heterocyclic small molecule DNA intercalator.[1]

Anwendung

BMH-21 has been used in cell culture.[2]

Biochem./physiol. Wirkung

BMH-21 has the ability to bind ribosomal DNA and prevent RNA polymerase I (Pol I) transcription and results in the disintegration of the nucleolus.[1][3] It does not impair DNA damage detection.[1] BMH-21 is considered as an important activator of the p53 pathway.[3]

BMH-21 is a potent inhibitor of RNA Pol I.

BMH-21 is a potent inhibitor of RNA Pol I. BMH-21 binds strongly to GC-rich DNA sequences, ultimately inhibiting RNA Pol I, blocking transcription and disrupting the nucleolar structure. BMH-1 causes dissociation of the RPA194 catalytic subunit from Pol I, and disassembly of Pol I:DNA complexes. The compound BMH-21 inhibits proliferation of a broad range of tumor cell lines.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable