SML0609

Teniposid

≥97% (HPLC)

• Synonym(e): 4′-Dimethyl-9-(4,6-O-2-thenyid)-epipodophyllotoxin, Tenoposide, VM-26
• Empirische Formel (Hill-System): C₃₂H₃₂O₁₃S
• CAS-Nummer: 29767-20-2
• Molekulargewicht: 656.65
• EG-Nummer: 249-831-2
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥97% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D -100 to -115°, c = 1 in chloroform/methanol (9:1)
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• SMILES String: [s]1c(ccc1)[C@H]2O[C@@H]3[C@H](O[C@H]([C@@H]([C@H]3O)O)O[C@H]4[C@@H]5[C@@H]([C@@H](c7c4cc8c(c7)OCO8)c6cc(c(c(c6)OC)O)OC)C(=O)OC5)CO2
• InChI: 1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31+,32-/m0/s1
• InChIKey: NRUKOCRGYNPUPR-QBPJDGROSA-N

Beschreibung

Anwendung

Teniposide has been used as a topoisomerase II inhibitor to study its effects on the flagellum length in Trypanosoma brucei.[1][2] It has also been used as a chemotherapeutic agent to study its interactions with piperazine(B87).[3]

Biochem./physiol. Wirkung

Teniposide (VM-26) is a Topoisomerase II inhibitor with antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA, inducing breaks in double stranded DNA and preventing repair.

Teniposide is a Topoisomerase II inhibitor with antitumor activity.

Teniposide is a derivative of podophyllotoxin and has been studied to treat several cancers. It acts during the late S phase or the early G2 phase of the cell cycle.[4]

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H350
• P-Sätze: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Carc. 1B
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable