SML0445

Clemastine fumarate salt

≥98% (HPLC)

• Synonym(e): (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt, (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt, 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt, 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt, Meclastine fumarate salt, Mecloprodine
• Empirische Formel (Hill-System): C₂₁H₂₆ClNO · C₄H₄O₄
• CAS-Nummer: 14976-57-9
• Molekulargewicht: 459.96
• EG-Nummer: 239-055-2
• MDL-Nummer: MFCD00137486
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329824727
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D +15 to +25°, c = 1 in methanol
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: DMSO: 5 mg/mL (clear solution; warmed)
• Lagertemp.: room temp
• SMILES String: OC(=O)\C=C\C(O)=O.CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3
• InChI: 1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1
• InChIKey: PMGQWSIVQFOFOQ-YKVZVUFRSA-N
• Angaben zum Gen: human ... HRH1(3269)

Beschreibung

Allgemeine Beschreibung

Clemastine fumarate is used to treat multiple sclerosis,[1] sneezing and rhinorrhea linked to common cold.[2] It stimulates oligodendrocyte progenitor cell (OPC) differentiation and myelination.[1]

Anwendung

Clemastine fumarate salt has been used as a stimulator of rodent oligodendrocyte generation and myelination in vitro and in vivo.[3]

Biochem./physiol. Wirkung

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic.

Leistungsmerkmale und Vorteile

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable