L7795

Levocetirizin -dihydrochlorid

≥98% (HPLC)

• Synonym(e): Levocetirizin -dihydrochlorid
• Empirische Formel (Hill-System): C₂₁H₂₅ClN₂O₃·2HCl
• CAS-Nummer: 130018-87-0
• Molekulargewicht: 461.81
• MDL-Nummer: MFCD07366507
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329817657
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Löslichkeit: H₂O: ≥23 mg/mL
• Lagertemp.: room temp
• SMILES String: Cl.Cl.OC(=O)COCCN1CCN(CC1)[C@H](c2ccccc2)c3ccc(Cl)cc3
• InChI: 1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/m1../s1
• InChIKey: PGLIUCLTXOYQMV-GHVWMZMZSA-N
• Angaben zum Gen: human ... HRH1(3269)

Beschreibung

Allgemeine Beschreibung

Levocetirizine dihydrochloride is the R-enantiomer of cetirizine and is used for treating seasonal allergic rhinitis and chronic idiopathic urticaria. The liver metabolizes 14% of levocetirizine and rest is excreted in urine.[1] The response of levocetirizine to histamine is comparatively higher to cetirizine.[2]

Anwendung

Levocetirizine dihydrochloride has been used as standard in the thin layer chromatography optimization[3] and in preparation of racemic cetirizine standard for subcritical fluid chromatography-tandem mass spectrometry analysis.[4]

Biochem./physiol. Wirkung

Levocetirizine dihydrochloride is a nonsedating type histamine H1-receptor antagonist; active isomer of cetirizine

Levocetirizine hydrochloride is a nonsedating antihistamine. It is a histamine H1-receptor antagonist, the active isomer of cetirizine. Levocetirizine has high bioavailability, high affinity for and occupancy of the H1 receptor.

Leistungsmerkmale und Vorteile

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302,H400
• P-Sätze: P273 - P301 + P312 + P330
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Acute 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable