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Merck

L6135

Sigma-Aldrich

Lektin aus Arachis hypogaea (Erdnuss)

biotin conjugate, lyophilized powder

Synonym(e):

Erdnuss-Agglutinin, PNA

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1 MG
€ 124,00
5 MG
€ 473,00

€ 124,00


Voraussichtliches Versanddatum10. April 2025


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1 MG
€ 124,00
5 MG
€ 473,00

About This Item

UNSPSC-Code:
12352202
NACRES:
NA.32

€ 124,00


Voraussichtliches Versanddatum10. April 2025


Bulk-Bestellung anfordern

Konjugat

biotin conjugate

Qualitätsniveau

Form

lyophilized powder

Mol-Gew.

120 kDa

Zusammensetzung

Protein, ≥80% Lowry

Kennzeichnungsgrad

~3 mol biotin per mol protein

Methode(n)

blood typing: suitable
fractionation: suitable

Löslichkeit

water: 1.00-1.10 mg/mL, clear to slightly hazy, colorless

Lagertemp.

2-8°C

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Allgemeine Beschreibung

Peanut lectin (PNA) is a lectin or an agglutinin from the legume, Arachis hypogaea,[1] found in peripheral venous blood in humans after ingestion of peanuts. PNA lectin is specific to the galactosyl (β-1,3) N-acetylgalactosamine.[1]

Anwendung

Lectin from Arachis hypogaea (peanut) has been used:
  • in enzyme-linked micro plate assay to detect β-D-galactose-N-acetylglucosamine[2]
  • in Immunohistochemical double staining[3]
  • Immunohistochemical double staining for the detection of germinal centers[4]
  • in enzyme-linked microplate assayto detect β-D-galactose-N-acetylglucosamine[2]

Biochem./physiol. Wirkung

PNA verklumpt keine normalen humanen Erythrozyten, bewirkt aber eine starke Verklumpung (Agglutination) von mit Neuraminidase behandelten Erythrozyten. PNA weist eine potente Anti-T-Aktivität auf, ähnlich der Anti-T-Aktivität in Humanseren. Das Lektin kann für die Unterscheidung zwischen humanen Lymphozyten-Untergruppen verwendet werden.
Lectin from Arachis hypogaea (peanut) functions as an antigenic determinant for Thomsen-Friedenreich antigen (TF)[5] and as mitogen for colorectal cancer stimulation cell division in normal colonic epithelium.[6] It is therefore used as tumor marker.[7]

Verpackung

Package size based on protein content.

Physikalische Form

Contains sodium citrate

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Die Dokumentenbibliothek aufrufen

In situ observation of germinal center cell apoptosis during a secondary immune response
Saitoh HA, et al.
Journal of Clinical and Experimental Hematopathology : JCEH, 46, 73-82 (2006)
Inhibition of influenza viral neuraminidase activity by collectins
Tecle T, et al.
Archives of Virology, 1731-1742 (2007)
Synthesis of glycopolymers and their multivalent recognitions with lectins
Ting SRS, et al.
Polym. Chem., 1, 1392-1412 (2010)
Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus--infected mice
GeurtsvanKessel CH, et al.
The Journal of Experimental Medicine, 206, 2339-2349 (2009)
Andreia Valença et al.
Experimental eye research, 202, 108292-108292 (2020-10-17)
Careful control of iron availability in the retina is central to maintenance of iron homeostasis, as its imbalance is associated with oxidative stress and the progression of several retinopathies. Ferritin, known for its role in iron storage and detoxification, has

Questions

1–3 of 3 Questions  
  1. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  2. How does the storage temperature relate to shipping conditions?

    1 answer
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

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  3. Is the peanut lectin (Lectin from Arachis hypogaea) a glycoprotein?  If so, what is the carbohydrate content?

    1 answer
    1. Peanut lectin is not a glycoprotein. Although peanut lectin binds specifically to a particular carbohydrate (beta-gal(1-->3)galNac) in other molecules, the lectin itself does not contain any carbohydrate.  Please see page 231 of the following paper: R. Banerjee, et al., "Crystal structure of peanut lectin, a protein with an unusual quaternary structure".  Proc. Nat. Acad. Sci., USA, 91, 227-231 (1994).

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