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L4268

Sigma-Aldrich

Lipopolysaccharide aus Klebsiella pneumoniae

Lipopolysaccharides from Klebsiella pneumoniae

purified by phenol extraction

Synonym(e):

LPS

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10 MG
€ 136,00
100 MG
€ 812,00

€ 136,00

Voraussichtliches Versanddatum02. April 2025

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10 MG
€ 136,00
100 MG
€ 812,00

About This Item

MDL-Nummer:
MFCD00131520
UNSPSC-Code:
12352201
NACRES:
NA.25

€ 136,00

Voraussichtliches Versanddatum02. April 2025

Bulk-Bestellung anfordern

Biologische Quelle

bacterial (Klebsiella pneumoniae)

Qualitätsniveau

200

Form

lyophilized powder

Aufgereinigt durch

phenol extraction

Verunreinigungen

<3% Protein (Lowry)

Farbe

white to faint yellow

Löslichkeit

water: 4.90-5.10 mg/mL, slightly hazy to turbid, colorless to faintly yellow

Versandbedingung

ambient

Lagertemp.

2-8°C

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Verwandte Kategorien

Allgemeine Beschreibung

This product is phenol extracted from Klebsiella pneumoniae. The source strain is ATCC 15380.

Biochem./physiol. Wirkung

Lipopolysaccharides (LPS) are localized in the outer layer of the membrane and are, in noncapsulated strains, exposed on the cell surface. They contribute to the integrity of the outer membrane, and protect the cell against the action of bile salts and lipophilic antibiotics.

Angaben zur Herstellung

The product is soluble in water (5 mg/ml) or cell culture medium (1 mg/ml) yielding a hazy, faint yellow solution. A more concentrated, though still hazy, solution (20 mg/ml) has been achieved in aqueous saline after vortexing and warming to 70-80 oC. Lipopolysaccharides are molecules that form micelles in every solvent. Hazy solutions are observed in water and phosphate buffered saline. Organic solvents do not give clearer solutions. Methanol yields a turbid suspension with floaters, while water yields a homogeneously hazy solution.

Sonstige Hinweise

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000419210
0000419210
0000419209
0000419209
0000410664

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Nora S Wolff et al.
Intensive care medicine experimental, 8(1), 47-47 (2020-08-26)
The microbiome has emerged as an important player in the pathophysiology of a whole spectrum of diseases that affect the critically ill. We hypothesized that differences in microbiota composition across vendors can influence murine models of pulmonary lipopolysaccharide (LPS) inflammation
Teresa García-Lezana et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 37(3), 927-937 (2016-05-08)
Hepatic encephalopathy has traditionally been considered a reversible disorder. However, recent studies suggested that repeated episodes of hepatic encephalopathy cause persistent impairment leading to neuronal loss. The aims of our study were the development of a new animal model that
Jinling Zhang et al.
Biosensors & bioelectronics, 99, 312-317 (2017-08-09)
We report a smartphone label-free biosensor platform based on grating-coupled surface plasmon resonance (GC-SPR). The sensor system relies on the smartphone's built-in flash light source and camera, a disposable sensor chip with Au diffraction grating and a compact disk (CD)
Max C Jacobs et al.
PloS one, 15(11), e0241748-e0241748 (2020-11-05)
An increasing body of evidence is indicating that the gut microbiota modulates pulmonary inflammatory responses. This so-called gut-lung axis might be of importance in a whole spectrum of inflammatory pulmonary diseases such as acute respiratory distress syndrome, chronic obstructive pulmonary
Sofia Monteiro et al.
Gut, 70(2), 379-387 (2020-04-04)
Systemic inflammation predisposes acutely decompensated (AD) cirrhosis to the development of acute-on-chronic liver failure (ACLF). Supportive treatment can improve AD patients, becoming recompensated. Little is known about the outcome of patients recompensated after AD. We hypothesise that different inflammasome activation
Alle zugehörigen Dokumente anzeigen

Artikel

Lipopolysaccharides for Research – Structure, Function & Applications

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

Verwandter Inhalt

Lipopolysaccharides

Lipopolysaccharide (LPS) is a major component of Gram-negative bacteria, important for microbiological research.

1 Review This action will navigate to reviews.

Questions

  1. Is the product LPS from K. pneumoniae Cat N L4268 Ultrapure? As prevention to minimisation effect of the mixture in cell culture

    1 answer

    1. This product is purified by phenol extraction and is not considered ‘Ultrapure’. Currently, the term ‘Ultrapure’ is not assigned to any of the LPS products. However, the method of purification is highly indicative of the type and amount of contaminants that may be present. Of the various methods of preparation and purification available, the most pure products are those purified by ion exchange chromatography followed by those purified by gel filtration. Unfortunately, a chromatography purified version of LPS from Klebsiella is not currently available.
      Please see the link below for more information on the results of this type of purification.
      https://www.sigmaaldrich.com/technical-documents/technical-article/research-and-disease-areas/cell-signaling/lipopolysaccharides

      Please see the link below to review LPS products sorted by the purification method:
      https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/research-and-disease-areas/immunology-research/lipopolysaccharides-for-research

      Please see the following link to review the general handling and usage information available for LSP products:
      https://www.sigmaaldrich.com/technical-documents/protocol/clinical-testing-and-diagnostics-manufacturing/bacteriology/lipopolysaccharides

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