G7798

GYKI-53655 hydrate

>99.0% (HPLC)

• Synonym(e): 1-(4-aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride, 5-(4-Aminophenyl)-8,9-dihydro-N,8-dimethyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide hydrochloride, LY300168 hydrochloride hydrate
• Empirische Formel (Hill-System): C₁₉H₂₀N₄O₃ · HCl · xH₂O
• CAS-Nummer: 143692-48-2
• Molekulargewicht: 388.85 (anhydrous basis)
• MDL-Nummer: MFCD01941362
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: >99.0% (HPLC)
• Form: powder
• Farbe: yellow to orange
• Löslichkeit: H₂O: >10 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: [Cl-].N1(N=C(c3c(cc4c(c3)OCO4)CC1C)c2ccc(cc2)N)C(=O)NC.[H+]
• InChI: 1S/C19H20N4O3.ClH/c1-11-7-13-8-16-17(26-10-25-16)9-15(13)18(22-23(11)19(24)21-2)12-3-5-14(20)6-4-12;/h3-6,8-9,11H,7,10,20H2,1-2H3,(H,21,24);1H
• InChIKey: ASLCSBBDVWPSQT-UHFFFAOYSA-N

Beschreibung

Anwendung

GYKI-53655 hydrate has been used as a calcium-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) receptor antagonist in single-particle tracking experiments.[1]

Biochem./physiol. Wirkung

GYKI-53655 also inhibits the kainate GluK3 homomeric and GluK2/3 heteromeric receptors.[2] It exhibits anti-ischemic, anti-convulsant, and acute neuroprotective activity.[3]

GYKI-53655 is an AMPA antagonist and noncompetitive negative allosteric modulator.

Leistungsmerkmale und Vorteile

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P264 - P270 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable