G5668

GW1929 hydrate

>98% (HPLC), solid

• Synonym(e): N-(2-Benzoylphenyl)-O-[2-(methyl-2-pyridinylamino)ethyl]-L-tyrosine hydrate
• Empirische Formel (Hill-System): C₃₀H₂₉N₃O₄ · xH₂O
• CAS-Nummer: 1049740-86-4
• Molekulargewicht: 495.57 (anhydrous basis)
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278789
• NACRES: NA.77

Eigenschaften

• Assay: >98% (HPLC)
• Form: solid
• Löslichkeit: DMSO: 20 mg/mL
• Ersteller: GlaxoSmithKline
• SMILES String: [H]O[H].CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c3ccccc3)C(O)=O)cc1)c4ccccn4
• InChI: 1S/C30H29N3O4.H2O/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23;/h2-18,27,32H,19-21H2,1H3,(H,35,36);1H2/t27-;/m0./s1
• InChIKey: XSITZVFUXCLFMK-YCBFMBTMSA-N
• Angaben zum Gen: human ... PPARG(5468)

Beschreibung

Anwendung

GW1929 has been used as a peroxisome proliferator-activated receptor γ (PPARγ) ligand:

• to study its effects on plant homeodomain finger protein 16 (Phf16) and patatin-like phospholipase domain containing 3 (Pnpla3) expression involved in adipogenesis
• to study its effects on complement component 3 (C3) gene expression in human hepatoma cells
• to activate PPARγ in human breast cancer cells

Biochem./physiol. Wirkung

GW1929 is a non-thiazolidinedione and is involved in cell growth inhibition and regulating gene expression. It exhibits neuroprotective effects against global cerebral ischemic-reperfusion injury by DNA fragmentation and minimizing the inflammation. GW1929 participates in the inhibition of α7 N-acetylcholine receptor expression and promoter activity. It also influences the early growth response-1 (Egr-1) protein expression.

GW1929 is a high affinity agonist of PPAR-γ.

Leistungsmerkmale und Vorteile

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Rechtliche Hinweise

Sold for research purposes only, pursuant to an agreement with Glaxo­Smith­Kline

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)