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G0897

Sigma-Aldrich

Genistin

from Glycine max (soybean), ≥95% (HPLC)

Synonym(e):

4′,5,7-Trihydroxyisoflavon-7-glucosid, Genistein 7-glucosid, Genistein-7-O-β-D-glucopyranosid, Genistosid, NSC 5112

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€ 67,20
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€ 235,00

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1 MG
€ 67,20
5 MG
€ 235,00

About This Item

Empirische Formel (Hill-System):
C21H20O10
CAS-Nummer:
529-59-9
Molekulargewicht:
432.38
Beilstein:
64479
MDL-Nummer:
MFCD00016883
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24895028
NACRES:
NA.77

€ 67,20

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Biologische Quelle

Glycine max (soybean)

Qualitätsniveau

200

Assay

≥95% (HPLC)

Löslichkeit

DMSO: 10 mg/mL

Lagertemp.

−20°C

SMILES String

OC[C@H]1O[C@@H](Oc2cc(O)c3C(=O)C(=COc3c2)c4ccc(O)cc4)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-5-13(24)16-14(6-11)29-8-12(17(16)25)9-1-3-10(23)4-2-9/h1-6,8,15,18-24,26-28H,7H2/t15-,18-,19+,20-,21-/m1/s1

InChIKey

ZCOLJUOHXJRHDI-CMWLGVBASA-N

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Anwendung

Genistin has been used for immune reactivity against influenza viruses in vitro[1] and as an internal standard in isoflavones quantification.[2]

Biochem./physiol. Wirkung

Selektiver Inhibitor von Säugetier-Terminal Desoxynucleotidyltransferase (TdT), mit keinen messbaren Effekt auf Säugetier- oder mikrobielle DNA-Polymerasen.
Inactive analog of genistein; useful as a negative control for genistein and other tyrosine kinase inhibitors.

Leistungsmerkmale und Vorteile

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000223696
0000223696
0000189651
0000168610
0000168609

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1 of 8

Genistein analytical standard

Supelco

92136

Genistein

Daidzin analytical standard

Supelco

42926

Daidzin

Glycitein analytical standard

Supelco

43534

Glycitein

Glycitin United States Pharmacopeia (USP) Reference Standard

USP

1295855

Glycitin

Daidzein analytical standard

Supelco

16587

Daidzein

Genistein, Sojabohne A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC₅₀ = 2.6 µM).

Sigma-Aldrich

345834

Genistein, Sojabohne

Genistein primary reference standard

05360590

Genistein

Genistein Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1859

Genistein

T Hamakawa et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(21), 9306-9312 (1999-10-26)
Neurotrophic factors have well established roles in neuronal development and adult synaptic plasticity, but their precise role in synapse formation has yet to be determined. This paper provides the first direct evidence that neurotrophic factors in brain conditioned medium (CM)
Soy saponins meditate the progression of colon cancer in rats by inhibiting the activity of beta-glucuronidase and the number of aberrant crypt foci but not cyclooxygenase-2 activity.
Guo YW, et al.
ISRN Oncology, 2013 (2013)
Anna Hsu et al.
Experimental biology and medicine (Maywood, N.J.), 235(1), 90-97 (2010-04-21)
Previous studies have suggested that soy isoflavones exert anticarcinogenic effects against prostate cancer. We propose that soy extracts, containing a mixture of soy isoflavones and other bioactive components, would be a more potent chemo-preventive agent than individual soy isoflavones. We
Soha M Hamdy et al.
Toxicology and industrial health, 28(8), 746-757 (2011-11-18)
Breast cancer is the second leading cause of cancer death among women and the third most common cancer. In this study, we investigated the chemoprevention efficacy of each of soy genistin, selenium or a combination of them against breast cancer.
Lun-Cheng Kuo et al.
Applied microbiology and biotechnology, 94(5), 1181-1188 (2012-02-22)
In order to produce isoflavone aglycosides effectively, a process of isoflavone hydrolysis by Bacillus subtilis natto NTU-18 (BCRC 80390) was established. This process integrates the three stages for the production of isoflavone aglycosides in one single fermenter, including the growth
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Questions

1–2 of 2 Questions  

  1. What is the lambda max for genistin and what is the molar extinction coefficient at that wavelength?

    1 answer

    1. We have data from our QC labs here at Sigma on one of the Genistin products we offer, G0897. The solvent is 85% ethanol/15% water, and the lambda max is typically 262.0 or 262.5 nm. We measured the molar extinction coefficients at the lambda max for four different lots of G0897 back in the 1990s, and the average value was 39,800 M-1.Genistin is a derivative of Genistein. There is an entry for Genistein in the chemicals encyclopedia published by the Royal Society of Chemistry, with information for Genistin under that heading.According to the chemicals encyclopedia published by the Royal Society of Chemistry, 14th edition, entry #4391, uv max (85% ethanol) 262.5 nm (a 90.5)".The value of ""a 90.5"" is the same as an E0.1%, or the extinction coefficient for a 1 mg/mL (or 1 gram per Liter) solution.If one multiplies 90.5 (L/g) by the molecular weight of genistin (432.38 g/mole), you get 39,130 M-1. This is pretty close to the value of 39,800 from our data above."

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  2. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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