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G0897
Genistin
From Glycine max (soybean), ≥95% (HPLC), terminal deoxynucleotidyl transferase (TdT) inhibitor
Synonym(e):
4′,5,7-Trihydroxyisoflavon-7-glucosid, Genistein 7-glucosid, Genistein-7-O-β-D-glucopyranosid, Genistosid, NSC 5112
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
1 mg | Warenkorb auf Verfügbarkeit prüfen | € 69,90 |
5 mg | Warenkorb auf Verfügbarkeit prüfen | € 245,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C21H20O10
CAS-Nummer:
Molekulargewicht:
432.38
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
64479
Assay:
≥95% (HPLC)
Technischer Dienst
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Unterstützung erhaltenProduktname
Genistin, from Glycine max (soybean), ≥95% (HPLC)
biological source
Glycine max (soybean)
Quality Segment
assay
≥95% (HPLC)
solubility
DMSO: 10 mg/mL
storage temp.
−20°C
SMILES string
OC[C@H]1O[C@@H](Oc2cc(O)c3C(=O)C(=COc3c2)c4ccc(O)cc4)[C@H](O)[C@@H](O)[C@@H]1O
InChI
1S/C21H20O10/c22-7-15-18(26)19(27)20(28)21(31-15)30-11-5-13(24)16-14(6-11)29-8-12(17(16)25)9-1-3-10(23)4-2-9/h1-6,8,15,18-24,26-28H,7H2/t15-,18-,19+,20-,21-/m1/s1
InChI key
ZCOLJUOHXJRHDI-CMWLGVBASA-N
Application
Biochem/physiol Actions
Selektiver Inhibitor von Säugetier-Terminal Desoxynucleotidyltransferase (TdT), mit keinen messbaren Effekt auf Säugetier- oder mikrobielle DNA-Polymerasen.
Inactive analog of genistein; useful as a negative control for genistein and other tyrosine kinase inhibitors.
Features and Benefits
This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Dieser Artikel | |||
|---|---|---|---|
| description from Glycine max (soybean), ≥95% (HPLC) | description phyproof® Reference Substance | description analytical standard | description A cell-permeable, reversible, substrate competitive inhibitor of protein tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 = 2.6 µM). |
| assay ≥95% (HPLC) | assay ≥95.0% (HPLC) | assay ≥98.0% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 200 | Quality Level - | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C |
| solubility DMSO: 10 mg/mL | solubility - | solubility - | solubility DMSO: 200 mg/mL |
| biological source Glycine max (soybean) | biological source - | biological source - | biological source - |
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Lagerklasse
11 - Combustible Solids
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
PSA (Persönliche Schutzausrüstung)
Eyeshields, Gloves, type N95 (US)
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What is the Department of Transportation shipping information for this product?
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What is the lambda max for genistin and what is the molar extinction coefficient at that wavelength?
1 answer-
We have data from our QC labs here at Sigma on one of the Genistin products we offer, G0897. The solvent is 85% ethanol/15% water, and the lambda max is typically 262.0 or 262.5 nm. We measured the molar extinction coefficients at the lambda max for four different lots of G0897 back in the 1990s, and the average value was 39,800 M-1.Genistin is a derivative of Genistein. There is an entry for Genistein in the chemicals encyclopedia published by the Royal Society of Chemistry, with information for Genistin under that heading.According to the chemicals encyclopedia published by the Royal Society of Chemistry, 14th edition, entry #4391, uv max (85% ethanol) 262.5 nm (a 90.5)".The value of ""a 90.5"" is the same as an E0.1%, or the extinction coefficient for a 1 mg/mL (or 1 gram per Liter) solution.If one multiplies 90.5 (L/g) by the molecular weight of genistin (432.38 g/mole), you get 39,130 M-1. This is pretty close to the value of 39,800 from our data above."
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