Radikalfänger, der gemeinsam mit Fe2+ eingesetzt wird, um NO in Hirn, Niere, Leber und anderem Gewebe nachzuweisen.
Radikalfänger, der gemeinsam mit Fe2+ eingesetzt wird, um NO in Hirn, Niere, Leber und anderem Gewebe nachzuweisen. Die gleichzeitige direkte Messung von NO* und pO2 wurde beschrieben. Als Kupferchelatbildner wurde es eingesetzt, um Kupfer in biologischen Materialien durch ESR zu quantifizieren sowie als Inhibitor von Superoxiddismutase, Ascorbatoxidase und anderen Enzymen.
Biochem./physiol. Wirkung
Inhibiert die Induktion von Makrophagen-NO-Synthase.
Leistungsmerkmale und Vorteile
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To detect nitric oxide (NO) in the rat brain during lipopolysaccharide (LPS)-induced sepsis, electron paramagnetic resonance (EPR) was employed with the NO trapping technique, using an iron and N,N-diethyldithiocarbamate (DETC) complex. An X-band (about 9.5 GHz) EPR system detected a
The Journal of experimental biology, 223(Pt 1) (2019-12-05)
The hypothalamic-pituitary-adrenal (HPA) axis is under complex regulatory control at multiple levels. Enzymatic regulation plays an important role in both circulating levels of glucocorticoids and target tissue exposure. Three key enzyme pathways are responsible for the immediate control of glucocorticoids.
The cyclooxygenase (COX) reaction can be monitored by measurement of oxygen consumption, peroxidase co-substrate oxidation or prostaglandin (PG) detection. This protocol describes a procedure measuring cyclooxygenase activity by quantifying PGE2 produced by enzymatic conversion of arachidonic acid, in the presence
British journal of pharmacology, 175(24), 4480-4495 (2018-09-29)
Diethyldithiocarbamate (DDC) is a major metabolite of disulfiram that is a potential drug for alcoholism treatment. In the present study, we attempted to explore the possible effect of DDC on non-alcoholic fatty liver disease (NAFLD) and related fibrosis in vivo.
The Journal of investigative dermatology, 140(3), 656-665 (2019-08-30)
The expressions of LL-37 and KLK-5 were found to be altered in various dermatoses, including atopic dermatitis, psoriasis, and rosacea. However, the downstream inflammatory effect of LL-37 and KLK-5 is not as well studied. In addition, there is little high-quality
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