D2773

Dithranol

≥90% (HPLC)

• Synonym(e): 1,8,9-Anthracentriol, 1,8-Dihydroxy-9(10H)-anthracenon, 1,8-Dihydroxy-anthron, Anthralin
• Empirische Formel (Hill-System): C₁₄H₁₀O₃
• CAS-Nummer: 1143-38-0
• Molekulargewicht: 226.23
• UNSPSC Code: 12352201
• NACRES: NA.25
• PubChem Substance ID: 24893712
• EC Number: 214-538-0
• Beilstein/REAXYS Number: 2054360
• MDL number: MFCD00053409

Eigenschaften

• Quality Segment: 200
• assay: ≥90% (HPLC)
• form: solid
• mp: 178-181 °C (lit.)
• solubility: chloroform: 20 mg/mL, clear to very slightly hazy, yellow
• SMILES string: Oc1cccc2Cc3cccc(O)c3C(=O)c12
• InChI: 1S/C14H10O3/c15-10-5-1-3-8-7-9-4-2-6-11(16)13(9)14(17)12(8)10/h1-6,15-16H,7H2
• InChI key: NUZWLKWWNNJHPT-UHFFFAOYSA-N
• Gene Information: mouse ... Alox12(11684)

Beschreibung

General description

Dithranol (1, 8 - dihydroxy-9-anthrone) is also called as anthralin. It is a vital topical antipsoriatic drugs.[1] Dithranol, an athracene derivative, is a free radical generating mitochondrial poison that induces apoptosis in keratinocytes.

Application

Dithranol, a potential anti-psoriasis medication, may be used to study its safety, efficacy, metabolism and pharmacological profile. Dithranol may be used to study is physicochemical properties, as a reference compound and to develop effective drug delivery vehicles.[2] Dithranol may be used as a matrix for matrix assisted laser desorption/ionization imaging on a Fourier transform ion cyclotron resonance mass spectrometer.[3]

Other Notes

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Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves