PHR1524

Tamsulosin-Hydrochlorid

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): Tamsulosin -hydrochlorid, 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)-ethyl]-amino]-propyl]-2-methoxybenzolsulfonamid -hydrochlorid
• Empirische Formel (Hill-System): C₂₀H₂₈N₂O₅S · HCl
• CAS-Nummer: 106463-17-6
• Molekulargewicht: 444.97
• MDL-Nummer: MFCD00922997
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329823437
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material; pharmaceutical secondary standard
• Qualitätsniveau: 300
• Agentur: traceable to BP 876; traceable to Ph. Eur. Y0000650; traceable to USP 1643260
• API-Familie: tamsulosin
• Analysenzertifikat (CofA): current certificate can be downloaded
• Verpackung: ampule of 1 × 200 mg
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: -10 to -25°C
• SMILES String: Cl.CCOc1ccccc1OCCN[C@H](C)Cc2ccc(OC)c(c2)S(N)(=O)=O
• InChI: 1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1
• InChIKey: ZZIZZTHXZRDOFM-XFULWGLBSA-N
• Angaben zum Gen: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

Beschreibung

Allgemeine Beschreibung

Tamsulosin hydrochloride is a subtypeselective a₁A and a₁D adrenoceptor antagonist, which exists in two enantiomeric forms, of which the R-isomer is the pharmaceutically active component. It is used to reduce urinary obstruction and is also involved in relieving the symptoms associated with symptomatic benign prostatic hyperplasia.

Anwendung

Tamsulosin hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Tamsulosin ist ein α1A/1D-Adrenozeptor-Antagonist, der bei der Behandlung von BPH (benigner Prostatahyperplasie) verwendet wird. Seine Wirkung als α-Blocker beinflusst auch die Iris und führt zu Komplikationen bei Operationen am Grauen Star, bekannt als "Floppy Iris Syndrom".

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAC0288 in the slot below. This is an example certificate only and may not be the lot that you receive.

Empfohlene Produkte

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable