The British journal of psychiatry : the journal of mental science, 161, 113-115 (1992-07-01)
Minaprine (200 mg daily, either once or divided b.d.) was compared with amitriptyline (25-50 mg t.d.s.) over six weeks in 144 patients with major depression. Significant reductions in HRSD scores at the end of six weeks' treatment were recorded with
[Three cases of acute agranulocytosis: caused by minaprine?].
Y Bastion et al.
Presse medicale (Paris, France : 1983), 22(2), 82-83 (1993-01-23)
Antidepressant response follows an exponential decay curve: replication and extension.
W Boyer
Journal of clinical psychopharmacology, 17(5), 426-427 (1997-10-08)
Involvement of protein kinase C (PKC) activation in the regulation of acetylcholine (ACh) release from rat hippocampal slices by minaprine, [3(2-morpholinoethylamino)-4-methyl-6-phenylpyridazine] was investigated. Phorbol esters such as 4 beta-phorbol 12,13-dibutylate (PDBu) and 12-o-tetradecanoylphorbol 13-acetate (TPA) enhanced high K(+)-evoked [3H]ACh release
Subchronic (5 mg/kg daily for 9 consecutive days) but not acute minaprine treatment enhanced in vivo dopamine release in the limbic part of the striatum of rats as revealed by intracerebral microdialysis. Moreover, the same subchronic treatment with minaprine reduced
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