857390P

W146

(R)-3-Amino-(3-hexylphenylamino)-4-oxobutylphosphonic acid (TFA salt), powder

• Synonym(e): S1P1 Antagonist
• Empirische Formel (Hill-System): C₁₈H₂₈F₃N₂O₆P
• CAS-Nummer: 909725-62-8
• Molekulargewicht: 456.39
• MDL-Nummer: MFCD00036905
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Assay: >99% (TLC)
• Form: powder
• Verpackung: pkg of 1 × 1 mg (857390P-1mg); pkg of 1 × 10 mg (857390P-10mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand 857390P
• Lipid-Typ: sphingolipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

Compound 2a is a selective antagonist for human S1P1 (hS1P1) receptor activation by the physiological agonist S1P.

W146 is a sphingosine-1-phosphate 1 (S1P1) selective antagonist.[1]

Anwendung

W146 has been used:

• to verify the mode of action of sphingosine-1-phosphate (S1P) in human bone marrow derived mesenchymal stem cells (hMSCs ) and primary human hepatogenic profibrotic cells (hHPCs)[2]
• to study oxidative stress and drug treatment in granulosa cells[3]
• to evaluate its effects on transendothelial electrical resistance (TEER)[4]

Biochem./physiol. Wirkung

W146 acts as an orthosteric antagonist.[2] It is linked to blood lymphopenia and lung edema in mice.[1]

Verpackung

5 mL Amber Glass Screw Cap Vial (857390P-10mg)

5 mL Amber Glass Screw Cap Vial (857390P-1mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): No data available
• Flammpunkt (°C): No data available