S3944

SEW2871

Name: SEW2871
Brand: SIGMA
Price: 276 EUR

≥98% (HPLC), solid

Synonym(e):

5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 1,2,4-oxadiazole

Slide 1 of 1

Anmelden zur Ansicht der Organisations- und Vertragspreise.

Größe auswählen

1 MG

€ 276,00

5 MG

€ 892,50

€ 276,00

Warenkorb auf Verfügbarkeit prüfen

Großbestellung anfragen

Über diesen Artikel

Empirische Formel (Hill-System):

C₂₀H₁₀F₆N₂OS

CAS-Nummer:

256414-75-2

Molekulargewicht:

440.36

NACRES:

NA.77

PubChem Substance ID:

24724607

UNSPSC Code:

12352211

MDL number:

MFCD00096600

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

protect from light

Wichtige Dokumente

Gesamtdokumentation anzeigen

Fortfahren mit

Technischer Dienst

Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.

Unterstützung erhalten

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

white

mp

94.5-95.3 °C

solubility

DMSO: ≥10 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

FC(F)(F)c1cccc(c1)-c2noc(n2)-c3cc(-c4ccccc4)c(s3)C(F)(F)F

InChI

1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H

InChI key

OYMNPJXKQVTQTR-UHFFFAOYSA-N

Gene Information

human ... S1PR1(1901), S1PR2(9294), S1PR3(1903), S1PR4(8698), S1PR5(53637)

Ähnliche Artikel vergleichen

Vollständigen Vergleich anzeigen

Unterschiede anzeigen

1 of 4

Dieser Artikel	C2992	SML0143	SML0895
Sigma-Aldrich S3944 SEW2871	Sigma-Aldrich C2992 CFTR(inh)-172	Sigma-Aldrich SML0143 HC-067047	Sigma-Aldrich SML0895 AGI-6780
form solid	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition protect from light	storage condition -	storage condition desiccated	storage condition -
solubility DMSO: ≥10 mg/mL, H₂O: insoluble	solubility DMSO: ≥10 mg/mL, H₂O: insoluble	solubility DMSO: ≥15 mg/mL	solubility DMSO: 20 mg/mL, clear

Application

SEW2871 was used to mimic the effects of sphingosine-1 phosphate in HUVECs to study the innate immunity rendered by long pentraxin 3.[1]

SEW2871 has been used as a sphingosine-1 phosphate (S1P) receptor agonist to determine the effects of reconstituting plasma apolipoprotein M (ApoM) /S1P on vascular permeability in mice.

Biochem/physiol Actions

Novel, selective human sphingosine-1-phosphate subtype 1 (S1P1) receptor agonist.

SEW2871 is a selective agonist of spingosine-1 phosphate receptor. It exacerbates reperfusion arrhythmias by significantly prolonging the duration of ventricular tachycardia and ventricular fibrillation.[2] SEW2871 modulates inflammatory reactions by influencing lymphocyte homing and cell migration.[3] By the inhibition of proinflammatory molecules, SEW2871 reduces acute renal failure due to ischemia.[4]

Features and Benefits

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Light sensitive.

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number

Die passende Version wird nicht angezeigt?

Wenn Sie eine bestimmte Version benötigen, können Sie anhand der Lot- oder Chargennummer nach einem spezifischen Zertifikat suchen.

Suche nach COA

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Recruitment of mesenchymal stem cells and macrophages by dual release of stromal cell-derived factor-1 and a macrophage recruitment agent enhances wound closure.

Yang-Hee Kim et al.

Journal of biomedical materials research. Part A, 104(4), 942-956 (2015-12-26)

In this study, the wound closure of mouse skin defects was examined in terms of recruitment of mesenchymal stem cells (MSC) and macrophages. For the cells recruitment, stromal derived factor-1 (SDF-1) of a MSC recruitment agent and sphingosine-1 phosphate agonist

Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity.

Jasmin Fettel et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(2), 1711-1726 (2018-09-07)

Sphingosine-1-phosphate (S1P) is involved in the regulation of important cellular processes, including immune-cell trafficking and proliferation. Altered S1P signaling is strongly associated with inflammation, cancer progression, and atherosclerosis; however, the mechanisms underlying its pathophysiologic effects are only partially understood. This

Differential Tolerance to FTY720-Induced Antinociception in Acute Thermal and Nerve Injury Mouse Pain Models: Role of Sphingosine-1-Phosphate Receptor Adaptation.

Laura J Sim-Selley et al.

The Journal of pharmacology and experimental therapeutics, 366(3), 509-518 (2018-06-28)

The immunomodulatory prodrug 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol (FTY720), which acts as an agonist for sphingosine-1-phosphate (S1P) receptors (S1PR) when phosphorylated, is proposed as a novel pain therapeutic. In this study, we assessed FTY720-mediated antinociception in the radiant heat tail-flick test and in the

Involvement of Sphingosine 1-Phosphate in Palmitate-Induced Non-Alcoholic Fatty Liver Disease.

Frdoos Al Fadel et al.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 40(6), 1637-1645 (2016-12-23)

Ectopic lipid accumulation in hepatocytes has been identified as a risk factor for the progression of liver fibrosis and is strongly associated with obesity. In particular, the saturated fatty acid palmitate is involved in initiation of liver fibrosis via formation

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain.

Zhoumou Chen et al.

Proceedings of the National Academy of Sciences of the United States of America, 116(21), 10557-10562 (2019-05-10)

Neuropathic pain afflicts millions of individuals and represents a major health problem for which there is limited effective and safe therapy. Emerging literature links altered sphingolipid metabolism to nociceptive processing. However, the neuropharmacology of sphingolipid signaling in the central nervous

Alle zugehörigen Dokumente anzeigen

Global Trade Item Number

SKU	GTIN
S3944-1MG	04061826676905
S3944-5MG	04061833265086

Questions

Reviews

No rating value

Active Filters

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung

SEW2871