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NanoFabTx™ - Natural Folate Lipid Mix
for synthesis of folate functionalized liposomes for targeted delivery
Synonym(e):
Cholesterol, EggPC, Folate-PEG-DSPE, PE-PEG
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About This Item
UNSPSC-Code:
12352211
NACRES:
NA.21
Preise und Verfügbarkeit sind derzeit nicht verfügbar.
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Qualitätsniveau
Lagertemp.
−20°C
Anwendung
NanoFabTx™ Natural Folate Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of folate-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of therapeutic drug molecules for targeted drug delivery applications without the need for lengthy trial-and-error optimization.
NanoFabTx™ Natural Folate Lipid Mix is a lyophilized, curated, lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve liposomes of approximately 100nm in diameter. The synthesized folate-functionalized liposomes can be used to selectively target cells which overexpress folate receptors such as HeLa cells and delivery hydrophilic or hydrophobic drugs, including therapeutics that are thermo-sensitive.
NanoFabTx™ Natural Folate Lipid Mix is a lyophilized, curated, lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve liposomes of approximately 100nm in diameter. The synthesized folate-functionalized liposomes can be used to selectively target cells which overexpress folate receptors such as HeLa cells and delivery hydrophilic or hydrophobic drugs, including therapeutics that are thermo-sensitive.
Leistungsmerkmale und Vorteile
- A ready-to-use nanoformulation lipid blend for the synthesis of folate-functionalized liposomes without the need for high temepratures
- Step-by-step protocols developed and tested by our formulation scientists
- Flexible synthesis tool to create uniform and reproducible liposomes
- Optimized to make liposomes around 100 nm with low polydispersity
- Optimized lipid blend for folate-functionalized liposomes for therapeutic encapsulation
Rechtliche Hinweise
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
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Mahmoud M Omar et al.
International journal of nanomedicine, 16, 683-700 (2021-02-05)
To develop an externally triggered rapid-release targeted system for treating ovarian cancer, gemcitabine (GMC) was entrapped into sonosensitive (SoS) folate (Fo)-modified liposomes (LPs). GMC-loaded LPs (GMC LPs), GMC-loaded Fo-targeted LPs (GMC-Fo LPs), and GMC-loaded Fo-targeted SoS LPs (GMC-SoS Fo LPs)
Ho Yub Yoon et al.
International journal of nanomedicine, 14, 6249-6268 (2019-09-10)
To develop an intravesical instillation system for the treatment of bladder cancer, rapamycin (Rap) was encapsulated into liposomes and then homogeneously dispersed throughout a poloxamer 407 (P407)-based hydrogel. Rap-loaded conventional liposomes (R-CL) and folate-modified liposomes (R-FL) were prepared using a
Amit Verma et al.
Pharmaceutical research, 36(8), 123-123 (2019-06-21)
This investigation was aimed to explore the targeting potential of folate conjugated double liposomes (fDLs) bearing combination of synergistic drugs (Prednisolone and Methotrexate) for effective management of the rheumatoid arthritis (RA). To overcome the drawbacks of monotherapy, a combination of
Yan Tie et al.
Signal transduction and targeted therapy, 5(1), 6-6 (2020-04-17)
Tumor-associated macrophages (TAMs) facilitate cancer progression by promoting tumor invasion, angiogenesis, metastasis, inflammatory responses, and immunosuppression. Folate receptor β (FRβ) is overexpressed in TAMs. However, the clinical significance of FRβ-positive macrophages in lung cancer remains poorly understood. In this study
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