SRP6427

FGFR1/CD331 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

• 同義詞: BFGFR, CD331, CEK, FGFBR, FGFR-1, FLT2, H2, HBGFR, KAL2, N-SAM
• 分類程式碼代碼: 12352200
• NACRES: NA.32

屬性

• 生物源: human
• 重組細胞: expressed in HEK 293 cells
• 籤條: 6-His tagged (C-terminus)
• 化驗: ≥95% (SDS-PAGE)
• 形狀: lyophilized
• 分子量: calculated mol wt 40.1 kDa; observed mol wt 60-65 kDa by SDS-PAGE (DTT-reduced. Arg 22 is the predicted N-terminal.)
• 包裝: pkg of 20 and 100 μg
• UniProt登錄號: P11362
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... FGFR1(2260)

描述

一般說明

Fibroblast growth factor receptor 1 (FGFR1) is also known as basic fibroblast growth factor receptor 1(BFGFR1), FMS-like tyrosine kinase, CD331, and is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. This protein is one of several fibroblast growth factor receptors, which are related proteins that are involved in important processes such as cell division, regulation of cell growth and maturation, formation of blood vessels, wound healing, and embryonic development. The FGFR1 protein spans the cell membrane, so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell. This positioning allows the FGFR1 protein to interact with specific growth factors outside the cell and to receive signals that help the cell respond to its environment. When growth factors attach to the FGFR1 protein, the receptor triggers a cascade of chemical reactions inside the cell that instruct the cell to undergo certain changes, such as maturing to take on specialized functions. The FGFR1 protein is thought to play an important role in the development of the nervous system. This protein may also help regulate the growth of long bones, such as the large bones in the arms and legs.

The FGFR1 (fibroblast growth factor receptor 1) gene is mapped to human chromosome 8p11.23.[1] It codes for a cell-surface receptor tyrosine kinases and belongs to the FGFR family.[2]

生化／生理作用

Fgfr1 (fibroblast growth factor receptor 1) protein prevents endothelial to mesenchymal transition by downregulating transforming growth factor β. Fgfr1 thus helps in maintaining normal vascularity, which is generally affected by diabetes condition.[3] Upregulation of the FGFR1 gene indicates tumor progression and is observed in squamous cell carcinoma.[2]

外觀

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重構

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable