FGFR1
fibroblast growth factor receptor 1
Synonyms:
BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, KAL2, N-SAM, OGD, bFGF-R-1
Species:
Human FGFR1 (2260), Mouse Fgfr1 (14182), Rat Fgfr1 (79114), Domestic Rabbit FGFR1 (100351861), cow FGFR1 (281768), Horse FGFR1 (100057614), dog FGFR1 (475582), chicken FGFR1 (396516), naked mole-rat Fgfr1 (101700324), domestic guinea pig Fgfr1 (100731156)
UniProtKB ID:
Gene ID:
- Human(2260) Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
- Mouse(14182) fibroblast growth factor receptor 1
- Rat(79114) Fibroblast growth factor receptor 1
- Domestic Rabbit(100351861) fibroblast growth factor receptor 1
- cow(281768) fibroblast growth factor receptor 1
- Horse(100057614) fibroblast growth factor receptor 1
- dog(475582) fibroblast growth factor receptor 1
- chicken(396516) fibroblast growth factor receptor 1
- naked mole-rat(101700324) fibroblast growth factor receptor 1
- domestic guinea pig(100731156) fibroblast growth factor receptor 1
- domestic cat(101086055) fibroblast growth factor receptor 1
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ELISA
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-FGFR1 (Ab-154) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
western blot
Anti-phospho-FGFR1 (pTyr654) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-Phospho-FGFR1-Y653 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-FGFR1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-FGFR1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
FGFR1 Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human FGFR1 amino acids 456-765, for use in Kinase Assays.,
Species
human
FGFR1 (FLT2) (399-822), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
FGFR1 (V561M), active, GST tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
FGFR1 (V561M) Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human FGFR1 amino acids 456 -765 containing the V561 mutation. For use in Enzyme Assays.,
Species
human