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重要文件

P9386

Sigma-Aldrich

聚-L-组氨酸

mol wt 5,000-25,000

同義詞:

L-Histidine homopolymer

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About This Item

CAS號碼:
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.26
暫時無法取得訂價和供貨情況

形狀

powder or solid

分子量

5,000-25,000

顏色

white to light yellow

應用

cell analysis

儲存溫度

−20°C

SMILES 字串

[N+H3][C@@H](Cc1[nH]cnc1)C(=O)[O-]

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

InChI 密鑰

HNDVDQJCIGZPNO-YFKPBYRVSA-N

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一般說明

聚-L-组氨酸是一种两性化合物。结构中的咪唑环可进行质子化−去质子化反应。[1]

應用

聚L-组氨酸已用于:
  • 作为聚阳离子分散多壁碳纳米管(MWCNT)[2]
  • 作为多离子化合物研究其破坏细胞外包膜病毒膜的能力[3]
  • 通过在细胞水平上和在体内的抗朊毒体(prion)分析,进行其抗朊毒体活性筛选[4]

生化/生理作用

聚L-组氨酸(Phis)共聚物具有生物相容性、pH响应性和较低的毒性。它具有逃逸内溶酶体的功能。聚L组氨酸与聚乙二醇−聚(d,l-丙交酯) (PEG-PLA)的共聚物可有效递送阿霉素。[5]pH敏感性聚l-组氨酸共聚物胶束可在酸性微环境中递送抗癌药物。[6]

分析報告

分子量 (MALLS)。

其他說明

有关聚氨基酸的其他技术信息,请访问 聚氨基酸常见问题解答资源

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Rong Liu et al.
International journal of nanomedicine, 7, 4433-4446 (2012-08-28)
Two methoxyl poly(ethylene glycol)-poly(L-histidine)-poly(L-lactide) (mPEG-PH-PLLA) triblock copolymers with different poly(L-histidine) chain lengths were synthesized. The morphology and biocompatibility of these self-assembled nanoparticles was investigated. Doxorubicin, an antitumor drug, was trapped in the nanoparticles to explore their drug-release behavior. The drug-loaded
Wooram Park et al.
Biomaterials, 33(34), 8848-8857 (2012-09-11)
For long-term, sustained protein delivery, a new, star-shaped block copolymer composed of methoxy poly(ethylene glycol) (mPEG), branched oligoethylenimine (bOEI), and poly(l-histidine) (pHis) was synthesized via the multi-initiation and ring-opening polymerization (ROP) of His N-carboxy anhydride (NCA) on bOEI with a
Poly (l-histidine)-PEG block copolymer micelles and pH-induced destabilization
Lee ES, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 90(3), 363-374 (2003)
Frank Morgner et al.
Sensors (Basel, Switzerland), 11(10), 9667-9684 (2011-12-14)
Förster resonance energy transfer (FRET) from luminescent terbium complexes (LTC) as donors to semiconductor quantum dots (QDs) as acceptors allows extraordinary large FRET efficiencies due to the long Förster distances afforded. Moreover, time-gated detection permits an efficient suppression of autofluorescent
Preparation and evaluation of poly (L-histidine) based pH-sensitive micelles for intracellular delivery of doxorubicin against MCF-7/ADR cells
Jia N, et al.
Asian Journal of Pharmaceutical Sciences , 12(5), 433-441 (2017)

文章

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Questions

1–5 of 5 Questions  
  1. Is this an oral product and if so, what is the recommended dose? If not, how is this product used?

    1 answer
    1. This product is intended for research use only. It is not suitable for any other purpose, which includes, but is not limited to, unauthorized commercial use, in vitro diagnostic use, or therapeutic use in humans or animals. Currently, there is no available product suitable for human use.

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  2. Hello, I am interested in your product Poly-L-histidine (P9386). Could you please confirm what terminal groups are present at both the N- and C-termini of this polymer?

    1 answer
    1. This polymer has carboxyl and amino end groups. Further detailed studies have not been conducted.

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  3. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  4. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  5. What is this product's pKa?

    1 answer
    1. The pKa value is not determined.

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