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Merck
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重要文件

P4663

Sigma-Aldrich

聚L -精氨酸 盐酸盐

Poly-L-arginine hydrochloride

mol wt 5,000-15,000

同義詞:

L-Arginine homopolymer hydrochloride

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About This Item

CAS號碼:
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.26
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形狀

powder

品質等級

分子量

5,000-15,000

顏色

white to off-white

應用

cell analysis
detection

儲存溫度

−20°C

SMILES 字串

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

InChI 密鑰

PQEISBBDIRAKGR-LFELFHSZSA-N

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應用


  • 聚(乙烯基胺盐酸盐)、聚(二烯丙基二甲基氯化铵)、聚-L-赖氨酸和聚-L-精氨酸与脂质双分子层相互作用的界面静电。:该研究调查了聚-L-精氨酸盐酸盐与脂质双分子层之间的相互作用,为其在药物输送系统中的潜在应用提供了深入见解(McGeachy et al., 2018)。(McGeachy et al., 2018)。

品質

含有3%或更低的鸟氨酸残基。

分析報告

分子量基于前体聚-L-鸟氨酸的粘度。

其他說明

有关聚氨基酸的其他技术信息,请访问 聚氨基酸常见问题解答资源

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

Lot/Batch Number

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存取文件庫

M Miyamoto et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 52(1), 21-30 (2001-07-05)
The effects of the concentration and molecular weight of poly-L-arginine (poly-L-Arg) on the in vivo nasal absorption of fluorescein isothiocyanate-labeled dextran (MW, 4 kDa, FD-4) in rats were studied. When poly-L-Arg with a range of different molecular weights (MW, 8.9
Keerthi Nadimidla et al.
Biopolymers, 107(9) (2017-05-01)
Tau protein plays a major role in Alzheimer's disease. The tau protein loses its functionality by self-aggregation due to the two six-amino acid sequences VQIVYK and VQIINK of the protein. Hence it is imperative to find therapeutics that could inhibit
Poly-L-arginine enhances paracellular permeability via serine/threonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium.
Ohtake K, Maeno T, Ueda H, et al.
Pharmaceut. Res., 20, 1838-1845 (2003)
Ramsha Aamir et al.
International journal of molecular sciences, 22(21) (2021-11-14)
Ischemic stroke is the most common type of stroke and thrombolytic therapy is the only approved treatment. However, current thrombolytic therapy with tissue plasminogen activator (tPA) is often hampered by the increased risk of hemorrhage. Plasmin, a direct fibrinolytic, has
Analysis of transient and reversible effects of poly-L-arginine on the in vivo nasal absorption of FITC-dextran in rats.
Ohtake K, Natsume H, Ueda H, et al.
J. Controlled Release, 82, 263-275 (2002)

文章

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Questions

Reviews

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    • Reviews 2
    • Votes 2
    1 out of 5 stars.

    Poor quality product

    This product was useless as it could not be sterile filtered without clogging the membrane. We checked it on SDS PAGE and confirmed the presence of very high molecular weight aggregates. We will ask for a refund. This was found with two separate batches, so it was not a bad batch issue.

    Helpful?

    1. Response from MilliporeSigma:

      Thank you for taking the time to leave a review! We are sorry to hear that your experience did not meet expectations. We would like to learn more about your experience to see if there is anything we can do to help troubleshoot this issue. When you have a moment, please contact us by visiting https://www.sigmaaldrich.com/support/customer-support and submit a Report Product Issue ticket. We look forward to hearing from you soon!

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