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Merck
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文件

G7252

Sigma-Aldrich

Guanosine 5′-diphosphate tris salt from Saccharomyces cerevisiae

Type VI, ≥92.5%

同義詞:

GDP

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About This Item

經驗公式（希爾表示法）:
C10H15N5O11P2
CAS號碼:
103192-39-8
分子量：:
443.20
MDL號碼:
MFCD00058344
分類程式碼代碼:
41106305
PubChem物質ID:
329799961
NACRES:
NA.51

種類

Type VI

化驗

≥92.5%

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

NC(CO)(CO)CO.NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H15N5O11P2.C4H11NO3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;5-4(1-6,2-7)3-8/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);6-8H,1-3,5H2/t3-,5-,6-,9-;/m1./s1

InChI 密鑰

YWMHXINREUQYRO-GWTDSMLYSA-N

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相關類別

生化／生理作用

Guanosine 5′-diphosphate (GDP) is the diphosphate nucleoside of the purine guanine. GDP and GTP are involved in and may be used to study cell signaling via G-coupled protein receptors (GCPR) and guanine nucleotide exchange factors (GEF) and a variety of GTPases.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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Nicola M Martucci et al.
Biochimie, 94(2), 503-509 (2011-09-20)
The effect of pulvomycin on the biochemical and fluorescence spectroscopic properties of the archaeal elongation factor 1α from Sulfolobus solfataricus (SsEF-1α), the functional analog of eubacterial EF-Tu, was investigated. The antibiotic was able to reduce in vitro the rate of protein
Jason Lowery et al.
The Journal of biological chemistry, 286(42), 36898-36906 (2011-08-11)
ADP-ribosylation factors (ARFs) and their activating guanine nucleotide exchange factors (GEFs) play key roles in membrane traffic and signaling. All ARF GEFs share a ∼200-residue Sec7 domain (Sec7d) that alone catalyzes the GDP to GTP exchange that activates ARF. We
Antonio Castro-Castro et al.
The EMBO journal, 30(19), 3913-3927 (2011-08-30)
The activation of the Rac1 GTPase during cell signalling entails its translocation from the cytosol to membranes, release from sequestering Rho GDP dissociation inhibitors (RhoGDI), and GDP/GTP exchange. In addition to those steps, we show here that optimal Rac1 activation
Sara J Wright et al.
Genetics, 189(1), 165-176 (2011-07-14)
Heterotrimeric (αβγ) G proteins are crucial components of eukaryotic signal transduction pathways. G-protein-coupled receptors (GPCRs) act as guanine nucleotide exchange factors (GEFs) for Gα subunits. Recently, facilitated GDP/GTP exchange by non-GPCR GEFs, such as RIC8, has emerged as an important
Rachel Cooley et al.
Wellcome open research, 5, 20-20 (2020-06-27)
Targeting the interaction of proteins with weak binding affinities or low solubility represents a particular challenge for drug screening. The NanoLuc â ® Binary Technology (NanoBiT â ®) was originally developed to detect protein-protein interactions in live mammalian cells. Here we report
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