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重要文件

C2759

Sigma-Aldrich

Carbonyl Cyanide m-Chlorophenylhydrazone

≥97% (TLC), powder, mitophagy inducer

同義詞:

m-Cl-CCP, CCCP, 羰基氰酯-3-氯苯基腙

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About This Item

經驗公式(希爾表示法):
C9H5ClN4
CAS號碼:
分子量::
204.62
Beilstein:
1842102
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

product name

氰化羰基-3-氯苯腙, ≥97% (TLC), powder

品質等級

化驗

≥97% (TLC)

形狀

powder

顏色

yellow to orange

溶解度

DMSO: 100 mM

儲存溫度

−20°C

SMILES 字串

Clc1cccc(N\N=C(\C#N)C#N)c1

InChI

1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H

InChI 密鑰

UGTJLJZQQFGTJD-UHFFFAOYSA-N

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應用

羰基氰化物间氯苯腙(CCCP)已用于:
  • 抑制临床铜绿假单胞菌中的外排泵[1]
  • 抑制人Beas-2B支气管上皮细胞线粒体的氧化磷酸化活性[2]
  • 制备羰基氰化物氯苯腙溶液,分析秀丽隐杆线虫的氧化和线粒体应激及线粒体诱导作用[3]

生化/生理作用

羰基氰3-氯苯肼(CCCP)诱导哺乳动物细胞的有丝分裂吞噬。[3]CCCP抑制少量电子传递链(ETC)蛋白的表达。[2]线粒体中氧化磷酸化的质子载体(H+ 离子载体)和解耦体。表明对细胞钙有多种影响。抑制肝脂肪酶分泌,部分抑制pH梯度激活的刷状缘膜泡中Cl- 的摄取和Cl-/Cl- 交换活性。

象形圖

Skull and crossbones

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


分析證明 (COA)

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Comparison of Efflux Pump Involvement in Antibiotic Resistance Among Pseudomonas aeruginosa Isolates of Burn and Non-Burn Patients
Azimi L, et al.
Archives of Pediatric Infectious Diseases, 4(3), e36160-e36160 (2016)
In vivo Mitophagy Monitoring in Caenorhabditis elegans to Determine Mitochondrial Homeostasis
Palikaras, Konstantinos and Tavernarakis, Nektarios
Bio-protocol, 7(7), 875-880 (2017)
Alvin P Joselin et al.
Human molecular genetics, 21(22), 4888-4903 (2012-08-09)
Mutations in several genes, including Parkin, PTEN-induced kinase 1 (Pink1) and DJ-1, are associated with rare inherited forms of Parkinson's disease (PD). Despite recent attention on the function of these genes, the interplay between DJ-1, Pink1 and Parkin in PD
Vimal B Maisuria et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 6(15), 1802333-1802333 (2019-08-14)
Antibiotic resistance is spreading at an alarming rate among pathogenic bacteria in both medicine and agriculture. Interfering with the intrinsic resistance mechanisms displayed by pathogenic bacteria has the potential to make antibiotics more effective and decrease the spread of acquired
Yunseon Jang et al.
International journal of molecular sciences, 20(14) (2019-07-25)
Current therapeutics for Parkinson's disease (PD) are only effective in providing relief of symptoms such as rigidity, tremors and bradykinesia, and do not exert disease-modifying effects by directly modulating mitochondrial function. Here, we investigated auraptene (AUR) as a potent therapeutic

文章

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Questions

  1. What is the shelf life of C2759 in cell culture media?

    1 answer
    1. Product C2759 has not undergone cell culture testing. However, information about storage after reconstitution is available. It states, "Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C."

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