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重要文件

G8377

Sigma-Aldrich

鸟苷 5′-单磷酸 二钠盐 水合物

from yeast, ≥99%

同義詞:

5′-GMP-Na2, 5′-鸟苷酸 二钠盐 水合物

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About This Item

經驗公式(希爾表示法):
C10H12N5Na2O8P · xH2O
CAS號碼:
分子量::
407.18 (anhydrous basis)
Beilstein:
3586801
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51
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生物源

yeast

品質等級

化驗

≥99%

形狀

powder

溶解度

H2O: soluble 50 mg/mL, clear, colorless to faintly yellow

儲存溫度

room temp

SMILES 字串

O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H14N5O8P.2Na.H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18);;;1H2/q;2*+1;/p-2/t3-,5-,6-,9-;;;/m1.../s1

InChI 密鑰

MEKWJTZTMVQYSU-CYCLDIHTSA-L

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相關類別

應用

鸟苷5′-一磷酸适用于:
  • 在大气压,以及288.15、293.15和298.15K下测定核苷酸的密度和粘度以及0.0004至0.0014mol/kg溶液中的呋喃糖[1]
  • 检测和验证用于检测产生AMP和GMP的酶的transcreener法[2]
  • 在使用毛细管IC-MS/MS进行核苷酸定量分析过程中制备核苷酸标准品[3]

生化/生理作用

鸟苷5′-单磷酸(GMP)是一种核糖核苷单磷酸,其可在磷酸化成GTP后通过各种RNA聚合酶掺入核糖核酸(RNA)中。 鸟苷-5′-单磷酸(GMP)可用于研究谷氨酸能神经传递的调节过程。

包裝

无底玻璃瓶。内含物装在插入的融合锥内。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Roberto Farina Almeida et al.
Pharmacology, biochemistry, and behavior, 96(3), 306-311 (2010-06-23)
The glutamatergic system has received considerable attention over the last few years as potential target to develop anxiolytic drugs. Guanine based purines (GBPs) play an important neurmodulatory effect in the glutamatergic system. Several studies have shown the ability of the
Robbin R Vernooij et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 24(22), 5790-5803 (2018-01-10)
The photodecomposition mechanism of trans,trans,trans-[Pt(N3 )2 (OH)2 (py)2 ] (1, py=pyridine), an anticancer prodrug candidate, was probed using complementary Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR), transient electronic absorption, and UV/Vis spectroscopy. Data fitting using Principal Component Analysis (PCA) and
Marcelo Ganzella et al.
Purinergic signalling, 8(1), 49-58 (2011-09-02)
Overstimulation of the glutamatergic system (excitotoxicity) is involved in various acute and chronic brain diseases. Several studies support the hypothesis that guanosine-5'-monophosphate (GMP) can modulate glutamatergic neurotransmission. The aim of this study was to evaluate the effects of chronically administered
Simone Molz et al.
Brain research, 1231, 113-120 (2008-07-29)
Glutamate is the main excitatory neurotransmitter in the mammalian nervous system and is essential for its normal functions. However, overstimulation of glutamatergic system due to hyperactivation of NMDA receptors and/or impairment of glutamate reuptake system has been implicated in many
Volumetric and Viscometric Studies of Nucleosides, Nucleotides and Furanose Sugar in Aqueous Medium from 288.15 to 298.15 K.
Singh, M et al.
Iranian Journal of Chemistry and Chemical Engineering, 25, 53-66 (2006)

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ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

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