BM0019

BMS-777607

≥98% (HPLC)

• 同義詞: BMS-817378, N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, N-[4-[(2-Amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide
• 經驗公式（希爾表示法）: C₂₅H₁₉ClF₂N₄O₄
• CAS號碼: 1025720-94-8
• 分子量：: 512.89
• MDL號碼: MFCD16495773
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329774362
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 25 mg/mL, clear
• 儲存溫度: room temp
• SMILES 字串: ClC1=C(N)N=CC=C1OC2=CC=C(NC(C3=C(OCC)C=CN(C4=CC=C(F)C=C4)C3=O)=O)C=C2F
• InChI: 1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33)
• InChI 密鑰: VNBRGSXVFBYQNN-UHFFFAOYSA-N
• 基因資訊: human ... MET(4233)

描述

生化／生理作用

BMS-777607 is an ATP-competitive inhibitor of the Met kinase superfamily with IC₅₀ values of 1.8, 3.9, 4.3, and 1.1 nM, respectively, for Ron, Met, Tyro-3, and AxI kinases. BMS-777607 has been studied in a variety of cancer models and has shown anti-cancer activity, causing increased apoptosis, and decreased proliferation and migration, although it has also been shown to induce polyploidy, which may lead to chemoresistance.

BMS-777607 is an ATP-competitive inhibitor of the Met kinase superfamily.

RON kinase inhibitor (RONi, BMS-777607) decreases recepteur d′origine nantais (RON) signaling.[1] This Met kinase inhibitor represses prostate cancer metastatic phenotype in vitro, induced by hepatocyte growth factor.[2]

特點和優勢

BMS-777607 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

法律資訊

Sold for research purposes only under agreement from BMS.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable