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重要文件

A6664

Sigma-Aldrich

(4-脒苯基)甲磺酰氟盐酸盐 盐酸盐

serine protease inhibitor

同義詞:

p-APMSF, 对脒苯基甲磺酰氯盐酸盐 盐酸盐

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About This Item

經驗公式(希爾表示法):
C8H9FN2O2S · HCl
CAS號碼:
分子量::
252.69
Beilstein:
9083148
MDL號碼:
分類程式碼代碼:
12352202
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

化驗

≥97% (silver nitrate titration)

形狀

powder

mp

190-191 ºC

溶解度

H2O: 50 mM (Stable when aliquoted at −20°C. Half-life = 6 minutes in pH 7.0 buffer systems.)

儲存溫度

−20°C

SMILES 字串

Cl[H].NC(=N)c1ccc(CS(F)(=O)=O)cc1

InChI

1S/C8H9FN2O2S.ClH/c9-14(12,13)5-6-1-3-7(4-2-6)8(10)11;/h1-4H,5H2,(H3,10,11);1H

InChI 密鑰

KHLLRHIUKOJXLL-UHFFFAOYSA-N

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一般說明

4-氨基苯甲磺酰氟盐酸盐相对无毒。[1]

應用

4-氨基苯甲磺酰氟盐酸盐已用作:
  • 抑制剂鸡尾酒的组分,用于全血收集和血浆分离[2]
  • 十二烷基硫酸钠(SDS)样品缓冲液的组分,用于制备全细胞提取物[3]
  • 胰蛋白酶抑制剂,用于测量其抑制效率,并确定量子点荧光共振能量转移(FRET)式酶探针的功效[1]

生化/生理作用

4-氨基苯甲磺酰氟盐酸盐(p-APMSF)能抑制镰孢菌产生的胰蛋白酶样蛋白酶。[4]它还能够阻断牛Xa因子、人纤溶酶和人补体蛋白酶C1r和C1s。
具有赖氨酸或精氨酸底物特异性的丝氨酸蛋白酶的不可逆抑制剂。有效浓度是10-100 μM。
具有赖氨酸或精氨酸底物特异性的丝氨酸蛋白酶的不可逆抑制剂。有效浓度是10-100 μM。常用于表征新发现的蛋白酶。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Lifang Shi et al.
Analytical chemistry, 79(1), 208-214 (2006-12-30)
The paper describes the development and characterization of analytical properties of quantum dot-based probes for enzymatic activity and for screening enzyme inhibitors. The luminescent probes are based on fluorescence resonance energy transfer (FRET) between luminescent quantum dots that serve as
Anja I Pekkarinen et al.
Journal of agricultural and food chemistry, 50(13), 3849-3855 (2002-06-13)
The fungal disease Fusarium head blight occurs on wheat (Triticum spp.) and barley (Hordeum vulgare L.) and is one of the worldwide problems of agriculture. It can be caused by various Fusarium species. We are characterizing the proteinases of F.
R Laura et al.
Biochemistry, 19(21), 4859-4864 (1980-10-14)
p-(Amidinophenyl)methanesulfonyl fluoride (p-APMSF) has been synthesized and shown to be a specific, irreversible inhibitor of the class of plasma serine proteases which demonstrate substrate specificity for the positively charged side chains of the amino acid lysine or arginine. In equimolar
Yoshihiro Hayashi et al.
Cancer discovery, 8(11), 1438-1457 (2018-08-25)
Myelodysplastic syndromes (MDS) are heterogeneous hematopoietic disorders that are incurable with conventional therapy. Their incidence is increasing with global population aging. Although many genetic, epigenetic, splicing, and metabolic aberrations have been identified in patients with MDS, their clinical features are
Lacramioara Ivanciu et al.
Blood, 124(11), 1705-1714 (2014-05-30)
The membrane-dependent interaction of factor Xa (FXa) with factor Va (FVa) forms prothrombinase and drives thrombin formation essential for hemostasis. Activated platelets are considered to provide the primary biological surface to support prothrombinase function. However, the question of how other

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