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重要文件

B4750

Sigma-Aldrich

Nα-苯甲酰-DL-精氨酸 β-萘胺 盐酸盐

trypsin substrate

同義詞:

BANA, Nα-苯甲酰基-DL-精氨酸-2-萘酰胺 盐酸盐

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About This Item

經驗公式(希爾表示法):
C23H25N5O2 · HCl
CAS號碼:
分子量::
439.94
Beilstein:
3823291
EC號碼:
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.32
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化驗

≥98% (TLC)

形狀

powder

溶解度

DMF: 50 mg/mL, clear, colorless to faintly yellow

儲存溫度

2-8°C

SMILES 字串

Cl[H].NC(=N)NCCCC(NC(=O)c1ccccc1)C(=O)Nc2ccc3ccccc3c2

InChI

1S/C23H25N5O2.ClH/c24-23(25)26-14-6-11-20(28-21(29)17-8-2-1-3-9-17)22(30)27-19-13-12-16-7-4-5-10-18(16)15-19;/h1-5,7-10,12-13,15,20H,6,11,14H2,(H,27,30)(H,28,29)(H4,24,25,26);1H

InChI 密鑰

BNGRKDJZQIGWQF-UHFFFAOYSA-N

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應用

Nα-苯甲酰基-DL-精氨酸β-萘酰胺盐酸盐在BANA试验中作为底物用于评价Stefin的抑制活性。[1]它也已用作测定胰蛋白酶抑制剂Ki值的底物。[2]

生化/生理作用

Nα-苯甲酰基-DL-精氨酸-β萘酰胺盐酸盐(BANA)有助于测定组织蛋白酶B和木瓜蛋白酶的活性。[3]BANA测试也有助于确定牙周致病菌的牙周部位数量。[4]由口腔细菌在牙菌斑或舌苔中合成的挥发性硫化物(VSC)的存在可以通过其水解N-苯甲酰基-DL-精氨酸-2-萘酰胺的能力进行比色确认。[5]

基底

胰蛋白酶的显色底物。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Thomas E Rams et al.
Journal of periodontology, 88(10), 1042-1050 (2017-05-19)
The validity of using pretreatment Periodontal Screening and Recording (PSR) index sextant scores to estimate periodontal access surgery needs is evaluated in patients with chronic periodontitis before and after completion of non-surgical periodontal therapy. In 110 adults, pretreatment probing data
Neera Raghav et al.
Bioorganic chemistry, 75, 38-49 (2017-09-16)
Cathepsins have emerged as promising molecular targets in a number of diseases such as Alzeimer's, inflammation and cancer. Elevated cathepsin's levels and decreased cellular inhibitor concentrations have emphasized the search for novel inhibitors of cathepsins. The present work is focused
Marie-Hélène Weech et al.
Journal of experimental botany, 59(9), 2437-2448 (2008-05-20)
Arabidopsis thaliana (L.) Heynh. genotypes limited in their ability to mount either octadecanoid-dependent induced resistance (IR(-)) or systemic acquired resistance (SAR(-)) were used to characterize the roles of these pathways in plant-herbivore interactions. Molecular and biochemical markers of IR were
Ravinder Kaur et al.
Bioorganic chemistry, 104, 104174-104174 (2020-09-16)
Cathepsins have emerged as important targets in various tissues degenerative disorders due to their involvement in degradation of extracellular matrices and endogenous protein turnover. Elevated cathepsins levels vis-à-vis decreased concentration of endogenous inhibitors has been reported at different diseased sites.
Mervyn Sydney Turton et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 22(8), 740-746 (2017-06-01)
Although the association between periodontal disease (PD) and adverse pregnancy outcomes has gained recognition amongst antenatal healthcare workers, not much has changed in practice to address it. This prospective study tested the hypothesis that BANA (N-benzoyl-DL-arginine-2-naphthylamide), a diagnostic test for

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