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Merck
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文件

A5000

Sigma-Aldrich

对乙酰氨基酚

meets USP testing specifications, 98.0-102.0%, powder

同義詞:

4′-羟基乙酰苯胺, 4-乙酰氨基酚, N-(4-羟基苯基)乙酰胺, N-乙酰基-4-氨基苯酚, APAP, 扑热息痛

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About This Item

線性公式:
CH3CONHC6H4OH
CAS號碼:
分子量::
151.16
Beilstein:
2208089
MDL號碼:
分類程式碼代碼:
12352111
PubChem物質ID:
NACRES:
NA.25

agency

USP/NF
meets USP testing specifications

品質等級

化驗

98.0-102.0%

形狀

powder

mp

168-172 °C (lit.)

溶解度

DMSO: 5 M
ethanol: 50 mg/mL
H2O: very slightly soluble

應用

pharmaceutical (small molecule)

SMILES 字串

CC(=O)Nc1ccc(O)cc1

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

InChI 密鑰

RZVAJINKPMORJF-UHFFFAOYSA-N

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應用

镇痛剂。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

364.3 °F - Pensky-Martens closed cup

閃點(°C)

184.6 °C - Pensky-Martens closed cup

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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Mohammad A Rahman et al.
Scientific reports, 9(1), 6571-6571 (2019-04-27)
Cellular CYP2E1 is well-known to mediate alcohol- (ALC) and acetaminophen- (APAP) induced toxicity in hepatic and extra-hepatic cells. Although exosomes have been gaining importance in understanding mechanism of intra- and inter-cellular communication, the functional role of drug metabolizing cytochrome P450
Karel Allegaert et al.
Archives of disease in childhood, 98(6), 462-466 (2013-04-23)
There remains a need for alternative medical treatments for patent ductus arteriosus (PDA) closure in extreme preterm neonates because of therapeutic failure and adverse effects associated with non-selective cyclo-oxygenase inhibitors. Reports of an association between paracetamol exposure and PDA closure
Garry G Graham et al.
Drug safety, 28(3), 227-240 (2005-03-01)
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported
Mitchell R McGill et al.
Pharmaceutical research, 30(9), 2174-2187 (2013-03-07)
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism and activation were published more than 40 years ago.
Garry G Graham et al.
Inflammopharmacology, 21(3), 201-232 (2013-05-31)
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. Paracetamol is, on average, a weaker analgesic than NSAIDs or COX-2 selective

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