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Merck
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重要文件

A4438

Sigma-Aldrich

p-Acetamidophenyl β-D-glucuronide sodium salt

>98% (TLC)

同義詞:

Acetaminophen glucuronide, Paracetamol glucuronide

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About This Item

線性公式:
C14H16NO8Na
CAS號碼:
分子量::
349.27
MDL號碼:
分類程式碼代碼:
12352201
PubChem物質ID:
NACRES:
NA.25
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化驗

>98% (TLC)

形狀

powder

雜質

<6% water (Karl Fischer)

顏色

white to off-white

溶解度

water: 25 mg/mL, clear, colorless to light yellow

儲存溫度

−20°C

SMILES 字串

[Na+].CC(=O)Nc1ccc(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C([O-])=O)cc1

InChI

1S/C14H17NO8.Na/c1-6(16)15-7-2-4-8(5-3-7)22-14-11(19)9(17)10(18)12(23-14)13(20)21;/h2-5,9-12,14,17-19H,1H3,(H,15,16)(H,20,21);/q;+1/p-1/t9-,10-,11+,12-,14+;/m0./s1

InChI 密鑰

OINXIJJEOMGKPB-CYRSAHDMSA-M

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應用

Acetaminophen glucuronide (AA-Gluc) is used as a reference material in procedures that analyse urine and plasma for acetaminophen metabolites to indicate hepatotoxicity.

其他說明

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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T Andrew Clayton et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(34), 14728-14733 (2009-08-12)
We provide a demonstration in humans of the principle of pharmacometabonomics by showing a clear connection between an individual's metabolic phenotype, in the form of a predose urinary metabolite profile, and the metabolic fate of a standard dose of the
Scott A Reisman et al.
Toxicological sciences : an official journal of the Society of Toxicology, 109(1), 31-40 (2009-02-28)
Acetaminophen (AA) is a widely used antipyretic drug that causes hepatotoxicity at high doses. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that mitigates electrophilic stress from AA by inducing genes, such as NAD(P)H:quinone oxidoreductase 1 (Nqo1)
Carol R Gardner et al.
Toxicological sciences : an official journal of the Society of Toxicology, 125(2), 607-612 (2011-11-04)
Fenbendazole is a broad-spectrum anthelmintic drug widely used to prevent or treat nematode infections in laboratory rodent colonies. Potential interactions between fenbendazole and hepatotoxicants such as acetaminophen are unknown, and this was investigated in this study. Mice were fed a
Mayu Kakehi et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(2), 360-369 (2015-07-17)
There are various interspecies differences in xenobiotic-metabolizing enzymes. It is known that cats show slow glucuronidation of drugs such as acetaminophen and strong side effects due to the UGT1A6 pseudogene. Recently, the UGT1A6 pseudogene was found in the Northern elephant
Andrew Rowland et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 147-153 (2014-11-09)
This study characterized the kinetics, variability, and factors that affect UDP-glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake by HLM. Uptake affinities (assessed as Kd) of the high- and low-affinity components differed

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