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重要文件

A2093

Sigma-Aldrich

阿司匹林

meets USP testing specifications

同義詞:

乙酰水杨酸, 2-乙酰氧基苯甲酸, O-乙酰水杨酸, ASA, 阿司匹林

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About This Item

線性公式:
2-(CH3CO2)C6H4CO2H
CAS號碼:
分子量::
180.16
Beilstein:
779271
EC號碼:
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.21
暫時無法取得訂價和供貨情況

agency

USP/NF
meets USP testing specifications

品質等級

形狀

powder or crystals

mp

134-136 °C (lit.)

應用

pharmaceutical (small molecule)

SMILES 字串

CC(=O)Oc1ccccc1C(O)=O

InChI

1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)

InChI 密鑰

BSYNRYMUTXBXSQ-UHFFFAOYSA-N

基因資訊

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一般說明

阿司匹林(乙酰水杨酸)是一种非甾体类抗炎药。[1][2]它以白色结晶粉末形式存在[2] 且衍生自水杨酸。[2]

應用

阿司匹林已被用于:
  • 在13,14-二氢-15-酮基前列腺素F2α(PGFM)测定期间用作血液稳定剂[3]
  • 在形态发生分析中,评估BV-2小胶质细胞系的细胞活力[4]
  • [5]

生化/生理作用

通过抑制环氧化酶(前列腺素H合酶),对COX-1亚型具有更高的选择性,阻止前列腺素的产生。抗血栓作用是由于COX-1在血小板中的抑制作用,阻止血栓形成和血小板聚集。 对结直肠及其他实体肿瘤有化学预防作用。
阿司匹林是一种止痛和解热剂,可用于治疗关节炎中的发烧和疼痛。[6]它还与心血管疾病有关。[6]

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

482.0 °F

閃點(°C)

250 °C

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

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存取文件庫

Relationship between endotoxin and prostaglandin (PGE2 and PGFM) concentrations and ovarian function in dairy cows with puerperal endometritis
Mateus L, et al.
Animal Reproduction Science (2003)
Concise Clinical Pharmacology (2007)
Aspirin suppresses growth in PI3K-mutant breast cancer by activating AMPK and inhibiting mTORC1 signaling
Henry, et al.
Cancer Research, 77(3), 790-801 (2017)
Henry's Clinical Diagnosis and Management by Laboratory Methods E-book (2011)
Acetylsalicylic acid enhances the anti-inflammatory effect of fluoxetine through inhibition of NF-kB, p38-MAPK and ERK1/2 activation in lipopolysaccharide-induced BV-2 microglia cells
Yang JM, et al.
Neuroscience, 275, 296-394 (2014)

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How to dissolve Aspirin and minimize concentration for storage?

    1 answer
    1. This compound is soluble in ethanol at 50 mg/mL, in water at 3 mg/mL, and in 37 °C water at 10 mg/mL. Acetylsalicylic acid is not stable in aqueous solutions and will readily hydrolyze to salicylic acid. Minimal concentration and solution stability in ethanol have not been established.

      Helpful?

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