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重要文件

730998

Sigma-Aldrich

tBuBrettPhos

97%

同義詞:

t -BuBrett-Phos, t-Bu Brett Phos, tertButylBrettPhos, t -BuBrett Phos, t-BuBrettPhos, [3,6-二甲氧基-2′,4′,6′-三(1-甲基乙基)[1,1′-联苯基]-2-基]双(1,1-二甲基乙基)膦, tert-ButylBrettPhos

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About This Item

經驗公式(希爾表示法):
C31H49O2P
CAS號碼:
分子量::
484.69
MDL號碼:
分類程式碼代碼:
12352112
PubChem物質ID:
NACRES:
NA.22
暫時無法取得訂價和供貨情況

品質等級

化驗

97%

形狀

solid

反應適用性

reaction type: Cross Couplings
reagent type: ligand
reaction type: Arylations

reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction

reagent type: ligand
reaction type: C-X Bond Formation

reagent type: ligand
reaction type: Fluorinations

mp

166-170 °C

官能基

phosphine

SMILES 字串

COc1ccc(OC)c(c1P(C(C)(C)C)C(C)(C)C)-c2c(cc(cc2C(C)C)C(C)C)C(C)C

InChI

1S/C31H49O2P/c1-19(2)22-17-23(20(3)4)27(24(18-22)21(5)6)28-25(32-13)15-16-26(33-14)29(28)34(30(7,8)9)31(10,11)12/h15-21H,1-14H3

InChI 密鑰

REWLCYPYZCHYSS-UHFFFAOYSA-N

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一般說明

tBuBrettPhos是由 Buchwald 研究组开发的二烷基二芳基膦配体。它可以更高效地促进交叉偶联反应,并具有优于其它催化系统的反应活性。

tBuBrettPhos是一种膦配体,广泛应用于钯催化交叉偶联反应。[1]

應用

常见应用
  • Buchwald-Hartwig 胺化和 C-O 偶联
  • Suzuki,Negishi,Stille,Hiyama,Sonogashira 交叉耦合
  • α-芳基化反应


新应用:
  • 芳基和乙烯基三氟酸盐转化为溴化物和氯化物 [2]
  • 芳基三氟酸盐转化为芳基氟化物 [3]
  • O -乙酰氢肟酸乙酯的芳基化 [4]
  • 芳基氯化物和磺酸盐转化为硝基芳烃[5]

特點和優勢

  • 白色结晶固体
  • 空气和水分稳定
  • 热稳定
  • 高效
  • 宽官能团容差
  • 极佳的选择性和转化率

法律資訊

使用受美国专利 7858784约束

相關產品

產品號碼
描述
訂價

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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存取文件庫

Pd-Catalyzed Conversion of Aryl Chlorides, Triflates, and Nonaflates to Nitroaromatics.
Fors BP, et al.
Journal of the American Chemical Society, 131, 12898-12898 (2009)
Transition-metal-catalyzed cross-couplings through carbene migratory insertion
Xia Y, et al.
Chemical Reviews, 117(23), 13810-13889 (2017)
Pd-Catalyzed O-Arylation of Ethyl Acetohydroximate: Synthesis of O-Arylhydroxylamines and Substituted Benzofuran
Maimone TJ, et al.
Journal of the American Chemical Society, 132, 9990-9990 (2010)
Formation of ArF from LPdAr (F): Catalytic conversion of aryl triflates to aryl fluorides.
Watson DA, et al.
Science, 325, 1661-1661 (2009)
Xiaoqiang Shen et al.
Journal of the American Chemical Society, 132(40), 14076-14078 (2010-09-23)
The palladium-catalyzed conversion of aryl and vinyl triflates to aryl and vinyl halides (bromides and chlorides) has been developed using dialkylbiaryl phosphine ligands. A variety of aryl, heteroaryl, and vinyl halides can be prepared via this method in good to

相關內容

Catalexis 平台透過數位方式優化催化劑的選擇,以找出最有效的膦配位體來進行交叉耦合反應,從而增強催化作用。

Catalexis 平台透過數位方式優化催化劑的選擇,以找出最有效的膦配位體來進行交叉耦合反應,從而增強催化作用。

The Catalexis platform enhances catalysis by digitally optimizing catalyst selection to identify the most effective phosphine ligands for cross-coupling reactions.

Explore reliable, premium grade catalysis materials for your pharma or industrial project. Specialty chemicals and formulations are available in bulk quantities and volumes from a few grams to multi-metric tons with complete documentation to simplify your leap from development to commercialization.

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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
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      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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