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Merck

301485

Sigma-Aldrich

1-氯乙基氯甲酸酯

98%

别名:

ACE-Cl

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5 G
$58.90
25 G
$166.00

About This Item

线性分子式:
CH3CHClOCOCl
CAS号:
分子量:
142.97
Beilstein:
1747601
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

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蒸汽壓力

3.25 psi ( 20 °C)

品質等級

化驗

98%

形狀

liquid

折射率

n20/D 1.422 (lit.)

bp

118-119 °C (lit.)

密度

1.325 g/mL at 25 °C (lit.)

官能基

chloro

儲存溫度

2-8°C

SMILES 字串

CC(Cl)OC(Cl)=O

InChI

1S/C3H4Cl2O2/c1-2(4)7-3(5)6/h2H,1H3

InChI 密鑰

QOPVNWQGBQYBBP-UHFFFAOYSA-N

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一般說明

1-氯乙基氯甲酸酯可用作叔胺的选择性去烷化剂(dealkylating agent )。[1]

應用

氯甲酸 1-氯乙酯用于:
  • 用于天然荧光毛细管电泳和激光诱导荧光检测测定生物体液中多种药物滥用时的 N-脱甲基反应[2]
  • 硅保护醇选择性脱硅的催化剂[1]
  • 作为 N -脱甲基叔胺中的试剂,生成用于法医毒理学应用的药物代谢产物引用物质[3]
  • 作为从胺中裂解二苯甲基的试剂[4]

訊號詞

Danger

危險分類

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

104.9 °F - closed cup

閃點(°C)

40.5 °C - closed cup

個人防護裝備

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Efficient chemoselective deprotection of silyl ethers using catalytic 1-chloroethyl chloroformate in methanol
Yeom CE, et al.
Tetrahedron, 61(52), 12227-12237 (2005)
Preparation of< i> N</i>-demethylated drug metabolites for analytical purposes using 1-chloroethyl chloroformate.
Pelander A, et al.
Forensic Science International, 85(3), 193-198 (1997)
Efficient chemoselective deprotection of silyl ethers using catalytic 1-chloroethyl chloroformate in methanol.
Yeom C-E, et al.
Tetrahedron, 61(52), 12227-12237 (2005)
Tetrahedron, 62, 6869-6869 (2006)
Ahmed Alnajjar et al.
Electrophoresis, 25(10-11), 1592-1600 (2004-06-10)
Methods for separation and determination of multiple drugs of abuse in biological fluids using capillary electrophoresis (CE) with native fluorescence and laser-induced fluorescence (LIF) detection are described herein. Using native fluorescence, normorphine, morphine, 6-acetyl morphine (6-AM), and codeine were analyzed

Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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