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Merck

23181

Sigma-Aldrich

氯甲酸氯甲酯

≥98.0% (GC)

别名:

1-氯甲基氯甲酸酯, 氯甲基氯化碳, 氯甲氧羰基氯, 氯甲酸氯甲酯, 氯碳酸氯甲基酯

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About This Item

线性分子式:
ClCOOCH2Cl
CAS号:
分子量:
128.94
Beilstein:
506426
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

≥98.0% (GC)

形狀

liquid

折射率

n20/D 1.428

bp

107-108 °C (lit.)

密度

1.450 g/mL at 20 °C

儲存溫度

2-8°C

SMILES 字串

ClCOC(Cl)=O

InChI

1S/C2H2Cl2O2/c3-1-6-2(4)5/h1H2

InChI 密鑰

JYWJULGYGOLCGW-UHFFFAOYSA-N

應用

氯甲酸氯甲基酯作为关键反应物用于合成:
  • 双氯芬酸和氟芬那酸的新型氨基羰基氧甲酯
  • 环孢菌素 A 的高水溶性单甲氧基聚乙二醇前体药物
  • 3-乙酰氧基甲氧羰基-1-芳基-3-甲基三氮烯系列

象形圖

Skull and crossbonesCorrosion

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Inhalation - Skin Corr. 1B

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

203.0 °F - closed cup

閃點(°C)

95 °C - closed cup

個人防護裝備

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


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Lina Ribeiro et al.
Archiv der Pharmazie, 340(1), 32-40 (2007-01-09)
Aminocarbonyloxymethyl ester prodrugs are known to undergo rearrangement in aqueous solutions to form the corresponding N-acylamine side product via an O-->N intramolecular acyl transfer from the carbamate conjugate base. Novel aminocarbonyloxymethyl esters of diclofenac and flufenamic acid containing amino acid
E Carvalho et al.
Bioorganic & medicinal chemistry, 8(7), 1719-1725 (2000-09-08)
A series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes 5 was synthesised by the sequential reaction of 1-aryl-3-methyltriazenes with (i) chloromethyl chloroformate, (ii) NaI in dry acetone, and (iii) either the silver carboxylate or the carboxylic acids in the presence of silver carbonate. The hydrolysis
Hoon Cho et al.
Archives of pharmacal research, 27(6), 662-669 (2004-07-31)
The highly water-soluble monomethoxypoly(ethyleneglycol) (mPEG) prodrugs of cyclosporin A (CsA) were synthesized. These prodrugs were prepared by initially preparing intermediate in the form of carbonate at the 3'-positions of CsA with chloromethyl chloroformate, in the presence of a base to
Keivan Sadrerafi et al.
Drug design, development and therapy, 12, 987-995 (2018-05-08)
Our previous study indicated that carborane containing small-molecule 1-(hydroxymethyl)-7-(4'-(trans-3″-(3'″-pyridyl)acrylamido)butyl)-1,7-dicarbadodecaborane (hm-MC4-PPEA), was a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt). Nampt has been shown to be upregulated in most cancers and is a promising target for the treatment of many different types

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