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化驗
≥98.0% (GC)
形狀
liquid
折射率
n20/D 1.428
bp
107-108 °C (lit.)
密度
1.450 g/mL at 20 °C
儲存溫度
2-8°C
SMILES 字串
ClCOC(Cl)=O
InChI
1S/C2H2Cl2O2/c3-1-6-2(4)5/h1H2
InChI 密鑰
JYWJULGYGOLCGW-UHFFFAOYSA-N
應用
氯甲酸氯甲基酯作为关键反应物用于合成:
- 双氯芬酸和氟芬那酸的新型氨基羰基氧甲酯
- 环孢菌素 A 的高水溶性单甲氧基聚乙二醇前体药物
- 3-乙酰氧基甲氧羰基-1-芳基-3-甲基三氮烯系列
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Inhalation - Skin Corr. 1B
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類(WGK)
WGK 3
閃點(°F)
203.0 °F - closed cup
閃點(°C)
95 °C - closed cup
個人防護裝備
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Archiv der Pharmazie, 340(1), 32-40 (2007-01-09)
Aminocarbonyloxymethyl ester prodrugs are known to undergo rearrangement in aqueous solutions to form the corresponding N-acylamine side product via an O-->N intramolecular acyl transfer from the carbamate conjugate base. Novel aminocarbonyloxymethyl esters of diclofenac and flufenamic acid containing amino acid
Bioorganic & medicinal chemistry, 8(7), 1719-1725 (2000-09-08)
A series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes 5 was synthesised by the sequential reaction of 1-aryl-3-methyltriazenes with (i) chloromethyl chloroformate, (ii) NaI in dry acetone, and (iii) either the silver carboxylate or the carboxylic acids in the presence of silver carbonate. The hydrolysis
Archives of pharmacal research, 27(6), 662-669 (2004-07-31)
The highly water-soluble monomethoxypoly(ethyleneglycol) (mPEG) prodrugs of cyclosporin A (CsA) were synthesized. These prodrugs were prepared by initially preparing intermediate in the form of carbonate at the 3'-positions of CsA with chloromethyl chloroformate, in the presence of a base to
Drug design, development and therapy, 12, 987-995 (2018-05-08)
Our previous study indicated that carborane containing small-molecule 1-(hydroxymethyl)-7-(4'-(trans-3″-(3'″-pyridyl)acrylamido)butyl)-1,7-dicarbadodecaborane (hm-MC4-PPEA), was a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt). Nampt has been shown to be upregulated in most cancers and is a promising target for the treatment of many different types
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