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T8325

Sigma-Aldrich

TDZD-8

≥98% (HPLC), needles

Synonim(y):

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

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About This Item

Wzór empiryczny (zapis Hilla):
C10H10N2O2S
Numer CAS:
327036-89-5
Masa cząsteczkowa:
222.26
Numer MDL:
MFCD04973552
Kod UNSPSC:
12352200
Identyfikator substancji w PubChem:
329826879
NACRES:
NA.77

Próba

≥98% (HPLC)

Postać

needles

warunki przechowywania

protect from light

kolor

white

mp

63-64.4 °C

rozpuszczalność

DMSO: >10 mg/mL

temp. przechowywania

2-8°C

ciąg SMILES

CN1SC(=O)N(Cc2ccccc2)C1=O

InChI

1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

Klucz InChI

JDSJDASOXWCHPN-UHFFFAOYSA-N

Zastosowanie

TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.

Działania biochem./fizjol.

TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.

Cechy i korzyści

This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Uwaga dotycząca przygotowania

TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.
This page may contain text that has been machine translated.

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certyfikaty analizy (CoA)

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Sigma-Aldrich

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