This product is stable at ambient temperatures for relatively short periods of time. The item is shipped at ambient temperature. A transit time of up to 2 weeks or a brief temperature excursion will not impact the quality of this material. Upon delivery, this product should be stored at refrigerated at 2 - 8°C.
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T2577
Temozolomide
≥98% (HPLC), powder, DNA methylating agent
Synonim(y):
3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxamide, 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide, 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, NSC 362856
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 25 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 811,00 zł | |
| 100 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 2230,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C6H6N6O2
Numer CAS:
Masa cząsteczkowa:
194.15
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
811,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
Temozolomide, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 10 mg/mL, clear, H2O: insoluble
originator
Schering Plough
storage temp.
2-8°C
SMILES string
CN1N=Nc2c(ncn2C1=O)C(N)=O
InChI
1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
InChI key
BPEGJWRSRHCHSN-UHFFFAOYSA-N
General description
Temozolomide is a small lipophilic alkylating agent. It interacts covalently with the nucleophile microenvironment within DNA (Guanine residues). Due to this property temozolomide is considered a cytotoxic agent. The mechanism of action of TMZ is dependent upon its ability to hydrolyze DNA, resulting in DNA degradation and destruction of tumor cells. Malignant Glioma cells respond primarily to TMZ by G2/ M cell cycle arrest or in rare cases by apoptosis. Temozolomide is a DNA methylating agent and drug resistance-modifying agent; anti-tumor and anti-angiogenic. Temozolomide induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA and functional inactivation of DNA repair protein O(6)-alkylguanine DNA alkyltransferase (AGT) in base excision repair (BER) pathway.
Application
Temozolomide has been used for analyzing drug resistance mechanisms in glioblastoma cell lines. Temozolomide has been used to induce cytotoxic effects on glioblastoma cells to study the outcome of protein disulfide isomerase (PDI) inhibition.[1]
Biochem/physiol Actions
Temozolomide is a DNA methylating agent and drug resistance-modifying agent; anti-tumor and anti-angiogenic. Temozolomide induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA and functional inactivation of DNA repair protein O(6)-alkylguanine DNA alkyltransferase (AGT) in base excision repair (BER) pathway.
Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Preparation Note
Temozolomide is soluble in DMSO at a concentration that is greater than 20 mg/ml. It is insoluble in water.
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Ta pozycja | |||
|---|---|---|---|
| form powder | form - | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥99.0% (HPLC) | assay - | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 10 mg/mL, clear, H2O: insoluble | solubility - | solubility - | solubility DMSO: 2 mg/mL, clear |
| color white to light brown | color - | color - | color white to beige |
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Danger
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Klasa składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
Produkty
We presents an article on Autophagy in Cancer Promotes Therapeutic Resistance
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Powiązane treści
Autophagy in Cancer
Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| T2577-100MG | 04061835559268 |
| T2577-25MG | 04061835559275 |
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Is undissolved Temozolomide still stable if it was stored at RT for 3 days upon arrival?
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How long is this stable for between 2-8 degrees celsius?
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This product is not assigned an expiration date. Products that are robust in nature and extremely stable, in the original unopened container, are not assigned an expiration date or retest schedule. These products will have no dating reported on either the label or the Certificate of Analysis.
Products that are not assigned an expiration or retest date are covered by a warranty period of 1 year from the date of product shipment.
Full Product Dating Information may be reviewed at the link below: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/190/408/product-dating-information-ms.pdfHelpful?
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How long is Temozolomide stable for when dissolved as recommended, in DMSO at 10 mg/mL and storaged at 2-8C? Also, can the solution only be stored at 2-8C or can it be stored at -20C or -80C for long term storage
1 answer-
Wherever possible, solutions should be prepared fresh and used on the same day. However, should stock solutions need to be prepared in advance, store in aliquots at -20°C for up to 1 month. Allow aliquots to equilibrate to room temperature prior to opening. The long term storage at other temperatures is not determined. However, the published reference below may prove helpful:
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/j.2055-2335.2012.tb00145.xHelpful?
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Do you have a reference for the analysis of Temozolomide (Product No. T2577) in serum?
1 answer-
We have not confirmed the method in our labs here at Sigma, but see: Kim, H. et al., High-performance liquid chromatographic analysis and stability of anti-tumor agent temozolomide in human plasma. Journal of Pharmaceutical and Biomedical Analysis, 24(3), 461-468 (2001).
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Is Temozolomide (Product No. T2577) an active drug or a prodrug?
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Temozolomide is considered a prodrug. It is hydrolyzed in vivo to MTIC (monomethyl triazeno imidazole carboxamide). See: Kim, H. et al., High-performance liquid chromatographic analysis and stability of anti-tumor agent temozolomide in human plasma. Journal of Pharmaceutical and Biomedical Analysis, 24(3), 461-468 (2001).
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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