SRP6539

NQO1 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• Synonim(y): Azoreductase, DT-Diaphorase (DTD), Dioxin-inducible 1, Disphorase-4 (DIA4), Menadione Reductase, NAD(P)H Dehydrogenase (Quinine) 1 (NQO1), NAD(P)H Quinone Oxireductase, Phylloquinone Reductase, Quinone Oxidoreductase 1, Quinone Reductase 1 (QR1)
• Kod UNSPSC: 12352200
• NACRES: NA.77

Właściwości

• pochodzenie biologiczne: human
• rekombinowane: expressed in E. coli
• Próba: ≥90% (SDS-PAGE)
• Formularz: liquid
• masa cząsteczkowa: ~30 kDa (Human NQO1 aa 1-274 is fused at the C-terminus to a His-tag.)
• opakowanie: pkg of 10 and 50 μg
• zanieczyszczenia: <0.1 EU/μg endotoxin (LAL test)
• numer dostępu UniProt: P15559
• Warunki transportu: wet ice
• temp. przechowywania: −20°C
• informacje o genach: human ... NQO1(1728)

Opis

Opis ogólny

Research area: Cell signaling. NQO1 (NAD(P)H quinone dehydrogenase 1) is an obligate two-electron reductase. It is a cytoplasmic, homodimeric protein, with one FAD molecule per monomer. This gene is localized to human chromosome 16q23.[1][2] It shows a wide range of tissue expression.[3]

Działania biochem./fizjol.

NQO1 (NAD(P)H quinone dehydrogenase 1) uses NADH or NADPH as a reducing cofactor, and is characterized by its inhibition by dicoumarol. It is thought to confer protection against natural and exogenous quinones.[1] It is involved in the conversion of benzene derived quinones to less toxic hydroquinones, and participates in benzene-associated hematotoxicity. It is involved in the reduction and eventual activation of few chemotherapeutic drugs and of environmental carcinogens, such as heterocyclic amines, nitroaromatic compounds, and possibly cigarette smoke particulate.[2] C609T null variant of this gene is linked with breast cancer susceptibility in north Indian patients.[4] NQO1 is up-regulated in serous ovarian carcinoma, and this expression is linked with poor prognosis; hence, this gene has potential as biomarker for the same.[5]

Postać fizyczna

0.2 μm-filtered solution in 50 mM Tris-Cl, pH 8.0, containing 1 mM DTT.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H319
• Zwroty wskazujące środki ostrożności: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Klasyfikacja zagrożeń: Eye Irrit. 2
• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable