SML1875

(2S,6S)-Hydroxynorketamine hydrochloride

≥98% (HPLC)

• Synonim(y): (2S,6S)-2-Amino-2-(2-chlorophenyl)-6-hydroxy-cyclohexanone hydrochloride, (2S,6S)-HNK hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₂H₁₄ClNO₂ · HCl
• Numer CAS: 1430202-70-2
• Masa cząsteczkowa: 276.16
• Kod UNSPSC: 12352116
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Formularz: powder
• aktywność optyczna: [α]/D +95 to +115°, c = 1 in H₂O
• kontrola substancji: regulated under CDSA - not available from Sigma-Aldrich Canada
• warunki przechowywania: desiccated
• kolor: white to beige
• rozpuszczalność: H₂O: 25 mg/mL, clear
• temp. przechowywania: 2-8°C
• ciąg SMILES: [H]Cl.ClC1=CC=CC=C1[C@](CCC[C@@H]2O)(N)C2=O
• InChI: 1S/C12H14ClNO2.ClH/c13-9-5-2-1-4-8(9)12(14)7-3-6-10(15)11(12)16;/h1-2,4-5,10,15H,3,6-7,14H2;1H/t10-,12-;/m0./s1
• Klucz InChI: ZQJVHBJDLMIKJK-JGAZGGJJSA-N

Opis

Działania biochem./fizjol.

(2S,6S)-Hydroxynorketamine hydrochlorideKetamine is a metabolite associated with increased locomotor activity and motor incoordination.

(2S,6S)-Hydroxynorketamine hydrochlorideKetamine is a metabolite associated with increased locomotor activity and motor incoordination.
It has been found that the NMDAR antagonist (R,S)-ketamine must be metabolized to (2S,6S;2R,6R)-hydroxynorketamine (HNK) to have antidepressant effects. The (2R,6R)-HNK enantiomer appears to be the enantiomer most responsible for antidepressant effects, while (2S,6S)-hydroxynorketamine was associated with increased locomotor activity and motor incoordination. (2S,6S)-HNK, was also found to increase the function of the mammalian target of rapamycin (mTOR) 2-fold at 0.05 nM. (2S,6S)-HNK and (2R,6R)-HNK both inhibited intracellular concentrations of D-serine, an endogenous NMDA receptor co-agonist, with IC₅₀ values of 0.18 nM and 0.68 nM, respectively. Neither bind with high affinity to NMDA receptors, with Ki values of 21.19 μM and > 100 μM for (2S,6S)-HNK and (2R,6R)-HNK, respectively.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable