SMB00376

CDDO Methyl Ester

≥98% (HPLC)

• Synonim(y): 2-Cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid methyl ester, Bardoxolone Methyl, CDDO-Me
• Wzór empiryczny (zapis Hilla): C₃₂H₄₃NO₄
• Numer CAS: 218600-53-4
• Masa cząsteczkowa: 505.69
• Numer MDL: MFCD11983137
• Kod UNSPSC: 12352205
• Identyfikator substancji w PubChem: 329824977
• NACRES: NA.25

Właściwości

• Poziom jakości: 200
• Próba: ≥98% (HPLC)
• Formularz: powder
• Zastosowanie: metabolomics; vitamins, nutraceuticals, and natural products
• temp. przechowywania: −20°C
• ciąg SMILES: CC1(C)CC[C@]2(C(OC)=O)CC[C@@]([C@@]3([H])[C@]2([H])C1)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O
• InChI: 1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15-23-29(5)16-19(18-33)25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22-,24-,29-,30+,31+,32-/m0/s1
• Klucz InChI: WPTTVJLTNAWYAO-KPOXMGGZSA-N
• informacje o genach: human ... IKBKB(3551) , KEAP1(9817) , NFE2L2(4780) , PPARG(5468)

Opis

Opis ogólny

CDDO-Me is a synthetic triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties.[1] It is derived from the natural product oleanic acid.[2]

Zastosowanie

CDDO Methyl Ester has been used to test its effect on hepatocyte membrane transporters (HMTs) regulation and mitigation of cholestasis in hepatic ischemia-reperfusion injury (IRI).[3] It has also been used activator of NF E2 Related Factor 2 (NRF2) to study its role in preventing cell death in melanoma cells.[4]

Działania biochem./fizjol.

CDDO-Me inhibits inflammatory mediators including interleukin-6 (IL-6), IL-10, and IL-12. It enhances apoptosis induced by TNF and chemotherapeutic agents.[5] CDDO-Me exhibits anti-proliferative activity in osteosarcoma cells and enhances the effectiveness of chemotherapeutic agents by inducing an intrinsic mitochondrial-dependent apoptotic pathway. It can be used as an adjuvant treatment for advanced and fatal form of prostate cancer.[5]

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable