M7033

N^G-Methyl-L-arginine acetate salt

≥98% (TLC), powder, nitric oxide synthase inhibitor

• Synonim(y): N_ω-Methyl-L-arginine acetate salt, L-NMMA, N⁵-(Methylamidino)-L-ornithine acetate salt, N^G-Monomethyl-L-arginine acetate salt
• Wzór empiryczny (zapis Hilla): C₇H₁₆N₄O₂ · C₂H₄O₂
• Numer CAS: 53308-83-1
• Masa cząsteczkowa: 248.28
• Beilstein: 6674255
• Numer MDL: MFCD00069311
• Kod UNSPSC: 12352209
• Identyfikator substancji w PubChem: 24278043
• NACRES: NA.77

Właściwości

• Nazwa produktu: N^G-Methyl-L-arginine acetate salt, ≥98% (TLC)
• Poziom jakości: 200
• Próba: ≥98% (TLC)
• Formularz: powder
• rozpuszczalność: water: 49.00-51.00 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• ciąg SMILES: CC(O)=O.CNC(=N)NCCC[C@H](N)C(O)=O
• InChI: 1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
• Klucz InChI: IKPNWIGTWUZCKM-JEDNCBNOSA-N
• informacje o genach: human ... NOS1(4842) , NOS2(4843) , NOS3(4846) ; mouse ... Nos2(18126) ; rat ... Nos1(24598) , Nos2(24599)

Opis

Zastosowanie

N^G-Methyl-L-arginine acetate salt has been used:

• as an inhibitor of nitric oxide synthase (NOS) in wound healing studies in injured mice[1]
• as an inhibitor of nitric oxide synthase (NOS) to study nitric oxide (NO) immunosuppressive effect of murine stem cells[2]
• as an inhibitor to monitor NO levels in hemocytes respiratory burst assay[3]

Działania biochem./fizjol.

N^G-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages.[4] It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine.[5] It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.[6]

Cechy i korzyści

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)