The storage stability temperature for this product is validated at -20°C. However, the product is shipped at ambient temperature. Shipping routes are configured to minimize transit time. Freezer storage products that ship at ambient temperature are considered stable up to 2 weeks for transit time.
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H5388
Hyaluronic acid sodium salt from rooster comb
avian glycosaminoglycan polysaccharide
Synonim(y):
Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating
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| Do Państwa/SKU | Dostępność | Cena netto |
|---|---|---|
100 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 851,00 zł |
250 mg | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 1770,00 zł |
1 g | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 4430,00 zł |
Informacje o tej pozycji
Numer CAS:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.25
MDL number:
851,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócbiological source
chicken (rooster comb)
Quality Segment
form
powder
impurities
≤2% protein (Lowry)
color
white
solubility
water: ~5 g/L
cation traces
Na: 3-7%
storage temp.
−20°C
SMILES string
[Na+].N([C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(=O)O)O)CO)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)O)O[C@@H]3[C@H]([C@@H](O[C@@H]([C@H]3O)CO)O)NC(=O)C)C(=O)O)C(=O)C
InChI
1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
InChI key
YWIVKILSMZOHHF-QJZPQSOGSA-N
Application
Hyaluronic acid sodium salt from rooster comb has been used:
- as a component of bi-layer gelatin scaffold
- as a vehicle for release of gentamicin during left ear surgery in guinea pigs
- in hyaluronic acid binding assay in human embryonic kidney cell line 293T
Biochem/physiol Actions
Hyaluronic acid is a polysaccharide present in the skin, connective tissue, vitreous humor and synovial fluid. It is essential for tissue hydration and functions to regenerate skin post injury or wounds. Hyaluronic acid, apart from having dermatologic and ophthalmologic applications, serves as a drug delivery vehicle. Hyaluronic acid also exhibits antioxidant and antiglycation properties.
High molecular mass polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine which forms the core of complex proteoglycan aggregates found in extracellular matrix.
Other Notes
To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
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Ta pozycja | |||
|---|---|---|---|
| biological source chicken (rooster comb) | biological source bacterial (Streptococcus zooepidemicus) | biological source - | biological source - |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level - |
| solubility water: ~5 g/L | solubility water: 20 mg/mL, clear, colorless | solubility water: 10 mg/mL | solubility - |
| form powder | form powder | form lyophilized | form - |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. - |
| impurities ≤2% protein (Lowry) | impurities - | impurities ≤0.070 EU/mg endotoxins (EU/mg NaHy), ≤0.1% protein | impurities - |
Klasa składowania
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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How long is the product (Hyaluronic Acid, Product # H5388) stable at room temperature?
1 answer-
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Mol Wt of H5388 (CAS Number 9067-32-7) Please share the Sodium Hyaluronate (g quantity) I am looking for Mol.Wt 100-200 Kda
1 answer-
This product has not been tested to determine the molecular weight. However, historical information indicates a range of 1.6 - 2 MDa. Currently, there is no product available at a molecular weight of 100-200 kDa. Product H7630, from bovine vitreous humor, has historically demonstrated a molecular weight of approximately 300 kDa. Please see the link below to review this product:
https://www.sigmaaldrich.com/product/sigma/h7630Helpful?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the purity of Hyaluronic acid, Product H5388?
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Sigma does not perform purity testing on this product due to the variable molecular weight and degradation that may occur in native glycosaminoglycans. This product is tested for activity and protein content which provide information regarding impurities and suitability.
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What is the molecular weight of Hyaluronic acid, Product H5388?
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Product No. H5388 is a linear heteropolysaccharide with repeating 3-O-(β-D-glucuronido)-N-acetyl-D-glucosamine units linked by β-(1-->4)) hexosaminidic bonds. The molecular weight of this subunit has not been determined, but could be calculated from the information above. Molecular weights of hyaluronic acids vary from 0.1-10 million, depending on the source. The hyaluronic acid from rooster comb is expected to have a molecular weight of 1-4 million.
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What is the solubility of Hyaluronic acid, Product H5388?
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For Sigma's analytical test, 15 mg of this product is dissolved in 5 mL of 0.3 M phosphate buffer, pH 5.35 at 25°C (i.e., 3 mg/mL).
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