The solubility of this product in DMSO has not been determined. However, various sources state that this product is soluble in DMSO at a minimum of 20 mg/mL.
Wszystkie zdjęcia(4)
Kluczowe dokumenty
H0888
Hydrocortisone
BioReagent, suitable for cell culture
Synonim(y):
11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M
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1 G
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1690,00 zł
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1 G
277,00 zł
5 G
1110,00 zł
10 G
1690,00 zł
About This Item
Wzór empiryczny (zapis Hilla):
C21H30O5
Numer CAS:
Masa cząsteczkowa:
362.46
Beilstein:
1354819
Numer WE:
Numer MDL:
Kod UNSPSC:
12352209
Identyfikator substancji w PubChem:
NACRES:
NA.77
Formularz:
powder
Próba:
≥98%
277,00 zł
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Polecane produkty
linia produktu
BioReagent
Poziom jakości
Próba
≥98%
Formularz
powder
metody
cell culture | mammalian: suitable
mp
211-214 °C (lit.)
rozpuszczalność
chloroform/ethanol (1:1): 50 mg/mL, clear, colorless to very faintly yellow
Warunki transportu
ambient
temp. przechowywania
room temp
ciąg SMILES
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
InChI
1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
Klucz InChI
JYGXADMDTFJGBT-VWUMJDOOSA-N
informacje o genach
human ... ABCB1(5243) , CYP3A4(1576) , NR3C1(2908) , SERPINA6(866)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126)
rat ... Ar(24208) , Nr3c1(24413)
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Zastosowanie
Działania biochem./fizjol.
Hydrocortisone (also referred to as cortisol) is an endogenous glucocorticoid which is secreted by the adrenal gland. It is produced from the hypothalamus–pituitary–adrenal (HPA) axis. Hydrocortisone interacts with glucocorticoid receptors and regulates various signaling pathways. It is associated with the induction of energy mobilization, increase in cerebral perfusion rates and local glucose consumption. It is also linked with increase in cardiovascular output and respiration, redistribution of blood, delivery of molecules and energy to the brain and muscles and modulation of immune responses.[3][4]
Primary glucocorticoid secreted by the adrenal cortex.
Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.
Postać fizyczna
powder-RT; stock-frozen in working aliquots, avoid repeated freeze/thaw
Rekonstytucja
To prepare 50 μg/mL stock solution, add 1.0 mL absolute ethanol to 1.0 mg of product, gently swirl to dissolve, add 19 mL sterile medium.
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Hasło ostrzegawcze
Danger
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Repr. 1A - STOT RE 2
Organy docelowe
Adrenal gland,Bone marrow
Kod klasy składowania
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
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Immunomodulation in septic shock: hydrocortisone differentially regulates cytokine responses.
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Fries E et al.
International Journal of Psychophysiology, 72, 67-67 (2009)
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Laminin-111 (Ln-1), an extracellular matrix (ECM) glycoprotein found in the basement membrane of mammary gland epithelia, is essential for lactation. In mammary epithelial cells (MECs), dystroglycan (Dg) is believed to be necessary for polymerization of laminin-111 into networks., thus we
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Can this compound be dissolved in DMSO, aliquoted to avoid the freeze thaw cycle, and store at -20C instead of chloroform:ethanol mixture?
1 answer-
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How long can the powder be stored after date of receipt?
1 answer-
This product, while considered stable, may be subject to degradation over time and is assigned a periodic retest date to confirm quality. The lot specific retest date is reported on the Certificate of Analysis. Please see the link below or navigate to the ‘DOCUMENTATION’ section of the Product Detail Page to access a sample or lot specific Certificate:
https://www.sigmaaldrich.com/US/en/product/sigma/h0888#product-documentationHelpful?
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How stable is hydrocortisone? I use it and supplement a medium but I administer it every 48 hours, can I have my stock for 7 days and it does not lose its effect or do I have to defrost it every time I use it so that it does not lose its effect?
1 answer-
The stability of this product in solution has not been determined. To assure optimum performance, it is recommended that solutions be stored in frozen aliquots at -20°C. However, the water soluble version of Hydrocortisone, available as product H0396, is estimated to be stable for 1 - 2 weeks when refrigerated at 2 - 8°C. Note that a publication, J. AM. PHARM. ASSOC., 49, 253 (1960), determined that solutions prepared in ethanol at 40mg/mL and stored at 25°C decline by 50% in potency after 160 days.
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Can it be dissolved completely in absolute ethanol, and stored per instructions (instead of 1:1 chloroform and ethanol)?
1 answer-
A stock solution can be prepared by reconstituting the product at 1 mg/ml in 100% EtOH. Gently swirl to dissolve. Then dilute to 50 ug/ml with sterile culture media, aliquot, and store at -20 °C. As a frozen aliquot, this should be stable for at least 3-4 months. Avoid the freeze/thaw cycle.
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