This product is soluble in water at 50 mg/mL. Sterile solutions should be stored at 2-8 °C. Long term solution stability of this product has not been determined. However, prepared solution products, such as G1272, have a shelf life of 2 years.
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G1264
Gentamicin sulfate salt
Gentamicin sulfate salt
powder, non-animal origin, suitable for cell culture, BioReagent
Synonim(y):
Gentiomycin C
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50 MG
268,00 zł
250 MG
590,00 zł
1 G
1760,00 zł
5 G
2260,00 zł
268,00 zł
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50 MG
268,00 zł
250 MG
590,00 zł
1 G
1760,00 zł
5 G
2260,00 zł
About This Item
Numer CAS:
Numer WE:
Numer MDL:
Kod UNSPSC:
12352207
eCl@ss:
42020823
Identyfikator substancji w PubChem:
NACRES:
NA.76
268,00 zł
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Poproś o zamówienie zbiorcze
Polecane produkty
Nazwa produktu
Gentamicin sulfate salt, powder, BioReagent, suitable for cell culture
pochodzenie biologiczne
Micromonospora purpurea
Poziom jakości
linia produktu
BioReagent
Formularz
powder
siła działania
~600 μg Gentamicin per mg
metody
cell culture | mammalian: suitable
kolor
white to off-white
spektrum działania antybiotyku
Gram-negative bacteria
Gram-positive bacteria
mycoplasma
Tryb działania
protein synthesis | interferes
temp. przechowywania
2-8°C
ciąg SMILES
O=S(O)(O)=O.O[C@]1(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@@](CC[C@H]3N)([C@@H](C)NC)[H])[C@@H](N)C[C@H]2N)OC1)NC.O[C@]4(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]5[C@@H](O)[C@H](O[C@H]6O[C@@](CC[C@H]6N)([C@@H](C)N)[H])[C@@H](N)C[C@H]5N)OC4)NC.O[
InChI
1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1
Klucz InChI
RDEIXVOBVLKYNT-HDZPSJEVSA-N
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Opis ogólny
Chemical structure: aminoglycoside
Gentamicin, also known as gentiomycin C, is an aminoglycoside, which is naturally produced by Gram-negative bacteria. This antibiotic functions by preventing protein synthesis.[1] Gentamicin sulfate prevents the growth of both Gram positive and Gram negative bacteria, in vivo and in vitro. In tissue culture, gentamicin sulfate is used to inhibit the growth of various strains of mycoplasma.[2]
Zastosowanie
Działania biochem./fizjol.
Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site. The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.
Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.
Antimicrobial spectrum: Includes Gram-negative and Gram-positive bacteria, including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.
Komponenty
Gentamicin is an aminoglycoside complex produced by fermentation of Micromonospora purpurea or M. echinospora. It is used as the sulfate salt. There are three components, each consisting of five basic nitrogens and requiring five equivalents of sulfuric acid per mole of gentamicin base.
Przestroga
Sterile solutions should be stored at 2-8°C. Solutions have also been shown to be stable at room temperature and in boiling aqueous buffers of pH 2-142.
Komentarz do analizy
Solubility- freely soluble in water, practically insoluble in ethanol
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Hasło ostrzegawcze
Warning
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Skin Sens. 1
Kod klasy składowania
11 - Combustible Solids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Środki ochrony indywidualnej
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Produkty
Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic
Krzywa zabijania antybiotyków to eksperyment dawka-odpowiedź, w którym komórki ssaków są poddawane rosnącej ilości antybiotyku selekcyjnego.
Protokoły
Cultrex® Basement Membrane Extract (BME) is a soluble form of basement membrane purified from Engelbreth-Holm-Swarm (EHS) tumor.
3-D Culture Matrix™ Mouse Laminin I may be used as a gel or as a media additive to study cellular growth and differentiation in three dimensions in vitro.
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1. What is the solubility of this antibiotic in water? How many mg of the substance can dissolve in 1 mL of water? 2. After preparing a diluted solution of the antibiotic in water, where should it be stored, and what is the recommended storage duration?
1 answer-
Helpful?
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Where can I find molecular weight of this gentamicin sulfate
1 answer-
The molecular weights of each components are as follows:
Gentamicin C1 = 477.6
Gentamicin C2 = 463.6
Gentamicin C1a = 449.5.Please see the link below to review this product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/352/367/g1264pis.pdfHelpful?
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