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C174

Sigma-Aldrich

Corticosterone: HBC complex

≥91.5% (HPLC), free flowing powder, water-soluble stress hormone

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About This Item

Numer CAS:
50-22-6
Numer MDL:
MFCD00163376
Kod UNSPSC:
51111800
NACRES:
NA.77

product name

Corticosterone: HBC complex, free flowing powder

pochodzenie biologiczne

synthetic (organic)

sterylność

non-sterile

Próba

≥91.5% (HPLC)

Postać

free flowing powder

Warunki transportu

ambient

temp. przechowywania

room temp

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

Klucz InChI

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Zastosowanie

Corticosterone: HBC complex has been used:
  • in the intravenous and intraperitoneal administration of corticosterone to rats to test its effect on glucocorticoid and mineralocorticoid activity
  • to induce acute stress in mice
  • in Pulsatile treatment in mice to test its effect on clock gene period 1 transcription

Działania biochem./fizjol.

The complex of corticosterone with 2-hydroxypropyl-β-cyclodextrin (HBC) improves water solubility. HBC is a carrier molecule. Corticosterone is a rodent-specific primary adrenal corticosteroid. It displays affinity towards the glucocorticoid and mineralocorticoid receptors.

Rekonstytucja

Corticosterone content: 66.7 mg/g. When 1 g of complex is reconstituted with water to a total volume of 2.12 mL, a solution which is 90.8 mM in corticosterone is obtained. Corticosterone itself is virtually insoluble in water.

Inne uwagi

Preformed water-soluble complex of corticosterone and 2-hydroxypropyl-β-cyclodextrin. Package size is total weight of both the corticosterone and the 2-hydroxypropyl-β-cyclodextrin. Corticosterone content: 66.7 mg/g
This page may contain text that has been machine translated.

Piktogramy

Health hazardExclamation mark
GHS08,GHS07

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H302 + H312 + H332,H351

Klasyfikacja zagrożeń

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

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(2-Hydroxypropyl)-β-cyclodextrin powder, BioReagent, suitable for cell culture

Sigma-Aldrich

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Marlena Wosiski-Kuhn et al.
Psychoneuroendocrinology, 42, 165-177 (2014-03-19)
Diabetes and obesity are associated with perturbation of adrenal steroid hormones and impairment of hippocampal plasticity, but the question of whether these conditions recruit glucocorticoid-mediated molecular cascades that are comparable to other stressors has yet to be fully addressed. We
Jan Kroon et al.
Molecular metabolism, 47, 101179-101179 (2021-02-07)
Brown adipose tissue (BAT) displays a strong circadian rhythm in metabolic activity, but it is unclear how this rhythm is regulated. As circulating levels of corticosterone coincide with the rhythm of triglyceride-derived fatty acid (FA) uptake by BAT, we investigated
Angela M Ives et al.
Journal of virology, 91(13) (2017-04-14)
Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) infect and establish latency in peripheral neurons, from which they can reactivate to cause recurrent disease throughout the life of the host. Stress is associated with the exacerbation of clinical symptoms
CORT, Cort, B, Corticosterone, and now Cortistatin: Enough Already!
Hershel Raff
Endocrinology, 157(9), 3307-3308 (2016-07-29)
B L Conway-Campbell et al.
Journal of neuroendocrinology, 22(10), 1093-1100 (2010-07-24)
In vivo glucocorticoid (GC) secretion exhibits a distinctive ultradian rhythmicity. The lipophilic hormone can rapidly diffuse into cells, although only the pulse peak is of sufficient amplitude to activate the low affinity glucocorticoid receptor (GR). Discrete pulses readily access brain
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