A9361

Artemether

≥98% (HPLC)

• Synonim(y): Dihydroartemisinin methyl ether, Dihydroqinghaosu methyl ether, SM-224
• Wzór empiryczny (zapis Hilla): C₁₆H₂₆O₅
• Numer CAS: 71963-77-4
• Masa cząsteczkowa: 298.37
• Numer MDL: MFCD00866205
• Kod UNSPSC: 51101908
• Identyfikator substancji w PubChem: 329771050
• NACRES: NA.77

Właściwości

• Próba: ≥98% (HPLC)
• Formularz: powder
• aktywność optyczna: [α]/D +155 to +175°, c = 0.5 in methanol
• kolor: off-white to light brown
• rozpuszczalność: DMSO: ≥20 mg/mL
• inicjator: Novartis
• temp. przechowywania: room temp
• ciąg SMILES: CO[C@H]1OC2O[C@@]3(C)CCC4[C@H](C)CCC([C@H]1C)[C@@]24OO3
• InChI: 1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
• Klucz InChI: SXYIRMFQILZOAM-HVNFFKDJSA-N

Opis

Opis ogólny

Artemisinin (ART) is a natural compound present in Artemisia annua, a traditional Chinese plant. [1]

Zastosowanie

Artemether has been used:

• as an anti-schistosomal compound to test it effect on the larval stages of S. mansoni[2]
• to sensitize mouse embryonic fibroblasts (MEFs) and human osteosarcoma HT1080 cells to cysteine starvation (STV)-induced ferroptosis[1]
• to stimulate islets and its effect on α to β transdifferentiation[3]

Działania biochem./fizjol.

Artemether is a methyl ether derivative of artemisinin. It is used against multi-drug resistant strains of the malaria parasite, Plasmodium falciparum, and shows potential in treatment of schistosomiasis.

Artemether is an anti-antimalarial compound.

Artemisinin possesses a highly reactive endoperoxide bridge, which is core for its therapeutic potential. The endoperoxide bond reacts with iron in the erythrocytes with malarial parasite. This leads to the generation of reactive oxygen species (ROS) directly targeting the parasite. Artemisinin also regulates ferroptosis in tumor cells.[1] The α cell transcription factor Arx expression is reduced by artemether. Prolonged exposure of primary islets also resulted in loss if identity in endocrine cell types and their functionality.[3]

Cechy i korzyści

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02,GHS07
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H242,H302
• Zwroty wskazujące środki ostrożności: P210 - P235 - P280 - P301 + P312 - P370 + P378 - P410
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral - Org. Perox. D
• Kod klasy składowania: 5.2 - Organic peroxides and self-reacting hazardous materials
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable