M2319

Mefloquine hydrochloride

≥98% (HPLC), Cx36 and Cx50 blocker, powder

• Synonim(y): (AS)-rel-a-(2R)-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride
• Wzór empiryczny (zapis Hilla): C₁₇H₁₇ClF₆N₂O
• Numer CAS: 51773-92-3
• Masa cząsteczkowa: 414.77
• NACRES: NA.77
• PubChem Substance ID: 24724536
• UNSPSC Code: 12352202
• EC Number: 257-412-0
• MDL number: MFCD00797519
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Właściwości

• Nazwa produktu: Mefloquine hydrochloride, ≥98% (HPLC), powder
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white
• solubility: DMSO: soluble 38 mg/mL, H₂O: insoluble
• SMILES string: Cl[H].[H][C@@]1(CCCCN1)[C@@H](O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F
• InChI: 1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1
• InChI key: WESWYMRNZNDGBX-YLCXCWDSSA-N

Opis

Application

Mefloquine hydrochloride has been used:

• to treat cochlear organotypic cultures with various doses to evaluate its role in cellular pathway involved in apoptosis
• in screening for in vitro antischistosomal activity
• in cytotoxicity assay of glioblastoma cells

Biochem/physiol Actions

Mefloquine is broadly used as an antimalarial drug. It inhibits 80S ribosomes of Plasmodium. It has numerous side effects like anxiety, dizziness, tremor, headache, and hearing loss. Mefloquine damages cochlear and vestibular hair cells through apoptosis. It also damages spiral ganglion neurons, degenerates cortical neuron and disrupts neuronal calcium homeostasis.

Blocker of gap junction channels Cx36 and Cx50.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves