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68957

Sigma-Aldrich

Tris(2-carboxyethyl)phosphine hydrochloride

BioUltra, suitable for electrophoresis, SDS-PAGE tested

Synonim(y):

TCEP.HCL, TCEP

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About This Item

Wzór empiryczny (zapis Hilla):
C9H15O6P · HCl
Numer CAS:
51805-45-9
Masa cząsteczkowa:
286.65
Beilstein:
3724376
Numer MDL:
MFCD00145469
Kod UNSPSC:
12352128
Identyfikator substancji w PubChem:
329761275
NACRES:
NA.32

linia produktu

BioUltra

Próba

97.5-102.5%

Postać

powder

metody

electrophoresis: suitable

rozpuszczalność

H2O: soluble

przydatność

SDS-PAGE tested

ciąg SMILES

Cl[H].OC(=O)CCP(CCC(O)=O)CCC(O)=O

InChI

1S/C9H15O6P.ClH/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15;/h1-6H2,(H,10,11)(H,12,13)(H,14,15);1H

Klucz InChI

PBVAJRFEEOIAGW-UHFFFAOYSA-N

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Opis ogólny

Tris(2-carboxyethyl) phosphine hydrochloride (TCEP.HCL ) is a useful reducing agent for Sulphur and nitrogen-containing compounds. TCEP.HCL and the resultant oxide are water-soluble. TCEP.HCL has electron-rich phosphorus and oxygen atoms to combine with various metals, including Rh, Ir, and Pd. It rapidly complexes with Rh and Ir in dioxane at ambient temperature. It reduces disulfide linkages in a range of peptides and proteins in biological disulfide.

Zastosowanie

TCEP.HCL has been used in various bioconjugation applications, both in vitro and in vivo, to tag proteins and live organisms with great effectiveness under mild physiological circumstances. TCEP.HCL is suitable for varied biological and synthetic applications. At an acidic pH, TCEP.HCL can be used to convert organic disulfides to thiols in water irreversibly.
Water soluble reagent, used for selective reduction of disulfides. More stable than DTT and useful in mass spectrometry applications.

Cechy i korzyści

The product has the following benefits:

  • TCEP.HCL lowers reactive oxygen species levels.
  • It increases glutathione levels and mitochondrial content.
  • It has anti-cancer effects.

Komentarz do analizy

agarose gel electrophorese corresponds to requirements

Piktogramy

Corrosion
GHS05

Hasło ostrzegawcze

Danger

Zwroty wskazujące rodzaj zagrożenia

H314

Klasyfikacja zagrożeń

Eye Dam. 1 - Skin Corr. 1B

Kod klasy składowania

8A - Combustible corrosive hazardous materials

Klasa zagrożenia wodnego (WGK)

WGK 1

Certyfikaty analizy (CoA)

Poszukaj Certyfikaty analizy (CoA), wpisując numer partii/serii produktów. Numery serii i partii można znaleźć na etykiecie produktu po słowach „seria” lub „partia”.

Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Christopher R Schlieve et al.
Experimental eye research, 83(5), 1252-1259 (2006-08-29)
Retinal ganglion cells (RGCs) undergo apoptosis after axonal injury, in part regulated by an intracellular superoxide anion burst, for which the target(s) are unknown. Shifting the RGC redox state towards reduction and preventing sulfhydryl oxidation is neuroprotective in vitro and
Yiren Zeng et al.
Theriogenology, 162, 32-41 (2021-01-15)
Oocyte in vitro maturation (IVM) is a crucial process that determines subsequent in vitro embryo production. The present study investigated the effects of the antioxidant tris (2-carboxyethyl) phosphine hydrochloride (TCEP-HCL) on the in vitro maturation of porcine oocytes and in vitro developmental competence of
W H Fischer et al.
Rapid communications in mass spectrometry : RCM, 7(3), 225-228 (1993-03-01)
The suitability of the hydrochloride salt of tris(2-carboxyethyl)phosphine (TCEP) for in situ reduction with matrix-assisted laser desorption/ionization (MALDI) and liquid secondary ionization (LSI) mass spectrometry is evaluated. TCEP can be used to irreversibly reduce organic disulfides to thiols in water
Siming Chen et al.
Chemical communications (Cambridge, England), 49(12), 1226-1228 (2013-01-05)
A widely used reducing agent tris-(2-carboxyethyl) phosphine significantly promotes the reaction of cisplatin with Sp1 zinc finger protein. This discovery clarifies the reactivity of cisplatin towards Sp1 zinc finger protein and implies that the reactions of platinum drugs could be
Fang-Fang Cheng et al.
The Analyst, 139(16), 3860-3865 (2014-07-01)
The expression of microRNAs (miRNAs) is related to some cancer diseases. Recently, miRNAs have emerged as new candidate diagnostic and prognostic biomarkers for detecting a wide variety of cancers. Due to low levels, short sequences and high sequence homology among
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