PHR1045
Diethylene glycol
Pharmaceutical Secondary Standard; Certified Reference Material
Synonim(y):
DEG, 2,2′-Oxydiethanol, 2-Hydroxyethyl ether, Bis(2-hydroxyethyl) ether, Diglycol
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About This Item
Wzór liniowy:
(HOCH2CH2)2O
Numer CAS:
Masa cząsteczkowa:
106.12
Beilstein:
969209
Numer WE:
Numer MDL:
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
NACRES:
NA.24
Polecane produkty
klasa czystości
certified reference material
pharmaceutical secondary standard
Poziom jakości
agency
traceable to Ph. Eur. Y0000217
traceable to USP 1193265
gęstość pary
2.14 (vs air)
ciśnienie pary
0.01 mmHg ( 20 °C)
rodzina API
diethylene glycol
Certyfikat analizy
current certificate can be downloaded
temp. samozapłonu
442 °F
granice wybuchowości
2-12.3 %
metody
HPLC: suitable
gas chromatography (GC): suitable
współczynnik refrakcji
n20/D 1.447 (lit.)
tw
245 °C (lit.)
mp
−10 °C (lit.)
gęstość
1.118 g/mL at 25 °C (lit.)
Zastosowanie
cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)
format
neat
temp. przechowywania
2-30°C
ciąg SMILES
OCCOCCO
InChI
1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2
Klucz InChI
MTHSVFCYNBDYFN-UHFFFAOYSA-N
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Opis ogólny
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Diethylene glycol is a a four carbon dimer of ethylene glycol and finds applications as antifreeze, solvent, humectant, hydraulic fluid and brake fluid. It is a potential neuro- and nephrotoxin for humans. It may also be utilized in moisturizers, lubricants, emulsification agents, additives and solvents.
Diethylene glycol is a a four carbon dimer of ethylene glycol and finds applications as antifreeze, solvent, humectant, hydraulic fluid and brake fluid. It is a potential neuro- and nephrotoxin for humans. It may also be utilized in moisturizers, lubricants, emulsification agents, additives and solvents.
Zastosowanie
Diethylene glycol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography (HPLC).
Diethylene glycol may be used as a standard in the determination of diethylene glycol present in serum samples using gas chromatography (GC). It may also be used as a reference standard in validating the composition of diethylene glycol in propolis syrup consumed by intoxicated victims using nuclear magnetic resonance studies (NMR) and gas chromatography coupled with flame ionization detector (GC-FID).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Komentarz do analizy
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Inne uwagi
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Przypis
To see an example of a Certificate of Analysis for this material enter LRAC0277 in the slot below. This is an example certificate only and may not be the lot that you receive.
Polecane produkty
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
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Zastosowanie
Numer produktu
Opis
Cennik
Hasło ostrzegawcze
Warning
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Acute Tox. 4 Oral
Kod klasy składowania
10 - Combustible liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Temperatura zapłonu (°F)
280.4 °F - closed cup
Temperatura zapłonu (°C)
138 °C - closed cup
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Klienci oglądali również te produkty
Identification and quantification of diethylene glycol in pharmaceuticals implicated in poisoning epidemics: an historical laboratory perspective
Bar.BD, et al.
Journal of Analytical Toxicology, 31(6), 295-303 (2007)
Clinical parameters, postmortem analysis and estimation of lethal dose in victims of a massive intoxication with diethylene glycol
Ferrari.AL and Giannuzzi L
Forensic Science International, 153, 45-51 (2005)
Gas-chromatographic determination of ethylene glycol in serum
Porter H.W and Auansakul aA
Clinical Chemistry, 28, 75-78 (1982)
Tao Zhou et al.
Journal of separation science, 30(16), 2620-2627 (2007-09-21)
A simple and reliable HPLC method was developed for the simultaneous quantitative analysis of diethylene glycol (DEG) and propylene glycol (PG) in pharmaceutical products by precolumn derivatization. The derivatization reagent p-toluenesulfonyl isocyanate (TSIC, 10 microL, 20% in ACN v/v) was
Asuman C Kucuk et al.
Langmuir : the ACS journal of surfaces and colloids, 27(10), 6381-6388 (2011-04-16)
"Core-corona" type amphiphiles, which comprise double-decker-shaped POSSs (DDSQs) as the core and two or four di(ethylene glycol) (DEG) units as the coronae, have recently been reported to form a stable monolayer at the air-water interface. In this paper, another core-corona
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