I0800000

Isotretinoin

European Pharmacopoeia (EP) Reference Standard

• Synonim(y): 13-cis-Retinoic acid, Isotretinoin
• Wzór empiryczny (zapis Hilla): C₂₀H₂₈O₂
• Numer CAS: 4759-48-2
• Masa cząsteczkowa: 300.44
• Numer MDL: MFCD00079542
• Kod UNSPSC: 41116107
• Identyfikator substancji w PubChem: 329815327
• NACRES: NA.24

Właściwości

• pochodzenie biologiczne: synthetic
• klasa czystości: pharmaceutical primary standard
• agency: EP
• rodzina API: isotretinoin
• Postać: solid
• producent / nazwa handlowa: EDQM
• metody: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• mp: 172-175 °C (lit.)
• Zastosowanie: pharmaceutical (small molecule)
• format: neat
• ciąg SMILES: [H]\C(C(O)=O)=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C
• InChI: 1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-
• Klucz InChI: SHGAZHPCJJPHSC-XFYACQKRSA-N
• informacje o genach: human ... RARA(5914) , RARB(5915) , RARG(5916)

Opis

Opis ogólny

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Isotretinoin, a vital isomer of vitamin A, is implicated in the treatment of severe recalcitrant nodular acne disorder. It is the only drug known to operate against the major pathogenic factors of acne. It serves to diminish the sebaceous gland activity, thereby resulting in the correction of keratinization defect.

Zastosowanie

Isotretinoin may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

Działania biochem./fizjol.

13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action. The action of RA is mediated through RAR-β and RAR-α receptors. RA attenuates iNOS expression and activity in cytokine-stimulated murine mesangial cells. It induces mitochondrial membrane permeability transition, observed as swelling and as a decrease in membrane potential, and stimulates the release of cytochrome c implicating mechanisms through the apoptosis pathway. These activities are reversed by EGTA and cyclosporin A. RA also increases MMP-1 protein expression partially via increased transcription.

Opakowanie

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Inne uwagi

Sales restrictions may apply.

This page may contain text that has been machine translated.

Informacja o środkach bezpieczeństwa

• Piktogramy: GHS08,GHS07
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H315,H319,H335,H360FD
• Zwroty wskazujące środki ostrożności: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Klasyfikacja zagrożeń: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
• Organy docelowe: Respiratory system
• Kod klasy składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable